BLOOD CARDIOVASCULAR SYSTEM PART 1
FUNCTIONS of BLOOD transports substances & maintains homeostasis in the body
Hemo = blood hemophobia: fear of blood hemostasis: bleeding is under control hematocyte: blood cell hematemesis: vomiting blood hematuria: bloody urine hematopoiesis: formation of blood cells
Blood is a type of CT made up of scattered cells & a liquid matrix
What’s in blood? 1. Cells (45%) RBCs WBCs Platelets (plts) 2. Plasma (55%) water, a.a., proteins, carbohydrates, lipids, vitamins, hormones, electrolytes, cellular waste
Hematocrit vol of blood cells in a sample of blood blood centrifuged then % cells figured normal levels: Newborns: 55-68% 10 yr olds: 36-40% Women: 38-46% Men: 42-54%
RBCs erythrocytes, hematocytes, corpuscles formed in bone marrow shape: biconcave disc allows for optimal surface area for diffusion of O 2 & CO 2 5 million/mm3 no nucleus so no cell division live about 120 days then phagocytosed in liver & spleen
RBCs Functions 1. transport O 2 thru out body (lungs cells) hemoglobin: (hgb) large protein that O 2 attaches to inside RBC 2. transports CO 2 thru out body (cells lungs)
Hemoglobin
oxyhemoglobin: plenty of oxygen being carried in RBCs, blood is bright red deoxyhemoglobin: not carrying much oxygen, blood is burgundy-red
Iron critical element needed to make hgb & normal RBCs most of body’s Fe is in RBCs in heme portion
Erythropoietin hormone secreted by kidneys stimulates formation of more RBCs by bone marrow requires: vit B12 & Folic Acid
White Blood Cells (WBCs) leukocytes general function: defend the body against pathogens
White Blood Cells TypeNameFunctionPicture GranulocytesNeutrophils aka PMNs polymorpho- neutrophils very active in phagocyting bacteria & are present in large #s in pus of wounds, most common of all types, normal= 60% of WBCs (granular cytoplasm) Eosinophilsattack parasites, control allergic reactions 2% of WBC count
White Blood Cells typeNameFunctionPicture Granulocytes continued Basophilsproduces heparin (prevents blood clots) & histamines (inflammatory reaction) 1% of WBC Agranulaocytes (lacking granular cytoplasm) Monocytesprecursors of macrophages; 6% of WBC Lymphocytesmain cell of immune system 30% of WBC
Platelets (plts) thrombocytes cell fragments formed from megakaryocyte, live ~4 days help initiate formation of blood clots release clotting factors
Plasma 92% water Functions: transport nutrients, gases, vitamins, hormones maintain fluid & electrolyte balance maintains normal pH
Plasma Proteins 1. Albumins made in liver maintain osmotic pressure & blood vol. 2. Globulins α & β, from liver transport lipids & fat-soluble vitamins 3. Fibrinogen from liver, largest of plasma proteins in blood clotting fibrin
Hemostasis process of stopping bleeding 1. blood vessel spasm damaged vessel smooth muscle to contract slows or stops blood loss plts release serotonin (vasoconstrictor) 2. plt plug forms plts become sticky forming plug over damaged area 3. Coagulation forms hematoma/fibrinogen fibrin
Coagulation when tissue damaged damaged cells release prothrombin activator (with Ca++) prothrombin thrombin thrombin acts as enzyme to cause fibrinogen fibrin fibrin traps plts & RBCs to form hematoma (blood clot w/in vessel)
Coagulation Pathway
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