1. The Big 4 Carbohydrates Lipids Proteins Nucleic Acids Um…..What’s up Doc?

2. Monomers/Polymers Monomers: a single unit of a macromolecule Polymers: more than one unit of a macromolecule –Linked by covalent bonds

3. Monomers, Polymers and Macromolecules

4. CARBOHYDRATES SUGARS AND STARCHES

5. CARBOHYDRATES Three Types of Carbohydrates POLYSACCHARIDE (have 3 or more sugar units) DISACCHARIDES (have 2 sugar units) MONOSACCHARIDES (have 1 sugar unit)

6. Structure Carbohydrates are composed of carbon (C), hydrogen (H), and oxygen (O) atoms in approximately a 1:2:1 ratio.

7. MONOSACCHARIDES Simple Sugars Simple sugars, made of a single sugar unit. Examples: Glucose, Galactose, Fructose. Glucose is the most common simple sugar

8. Glucose Glucose, the main sugar in your blood. Glucose has 6 carbon atoms, 12 hydrogen atoms, and 6 oxygen atoms.

9. DISACCHARIDES Made of two simple sugars or monosaccharides. Examples:  SUCROSE = Glucose + Fructose (table sugar)  MALTOSE = Glucose + Glucose (malt sugar)  LACTOSE = Glucose + Galactose (milk sugar)

10. POLYSACCHARIDES Polysaccharides are made of three or more simple sugars or monosaccharides. They usually consist of thousands of connected monosaccharides. Examples: starch, cellulose, glycogen.

11. Complex Carbohydrates Are Often Used to Create Structures Cellulose is the most abundant macromolecule on earth – and you’re probably wearing it now.

12. Functions of Carbohydrates 1.Energy source for cells. 2.Provides support for plants. 3.Hard body covering for insects

13. LIPIDS (FATS)

14. Characteristics of Lipids Lipids are nonpolar organic molecules and, therefore, do not dissolve in water.

15. Examples Examples: bacon fat, vegetable oil, butter, margarine, wax.

16. Lipids are Hydrophobic Molecules That Exist In Three Primary Forms Sterol Fat Phospholipid

17. The Building Blocks of Lipids GLYCEROLGLYCEROL 3FATTYACIDS3FATTYACIDS

18. Molecular Structure of a Fat

19. Glycerol Glycerol is a three-carbon alcohol molecule usually obtained by the saponification of fats and used as a solvent.

20. Fatty Acids Fatty acids are long chains of carbon atoms with a -COOH group or carboxyl group at the end. Examples:

21. FATTY ACIDS SATURATEDUNSATURATED

22. Saturated Fatty Acids Saturated fatty acids have the maximum possible number of hydrogen atoms (H). H H H H H H H H H H H O H C C C C C C C C C C C C OH H H H H H H H H H H H

23. Unsaturated Fatty Acids Unsaturated fatty acids have double bonds, and therefore fewer hydrogen atoms (H). H H H H H H H H H H H H H H H H O H C C C C C C C C C C C C C C C C O H H H H H H H H H H H H H H H

24. At a Store Near You Beginning January 1, 2006, the FDA required that the amount of trans fat be listed on all food labels. The new line showing levels of trans fat

25. Solid or Liquid? FATA triglyceride that is solid at room temperature is called FAT. OILA triglyceride that is liquid at room temperature is called OIL.

26. Triglycerides The majority of fat in organisms consists of one type of polymer of lipids called triglycerides. alcohol glycerolfatty acidsTriglycerides are composed of alcohol glycerol and three fatty acids.

27. Phospholipids Phospholipids are made out of * glycerol, * 2 fatty acids & *phosphate group. Building block of cell membranes.

28. Hydrophilic Head Group And Hydrophobic Tails Are The Keys To Phospholipid Function

29. Phospholipids Form Double-Layered Biological Membranes

30. Steroids are also Lipids Note the four ring structure common to all sterols. Sterols are: 1) essential membrane components and 2) form many hormones.

31. Sterols As Hormones Estrogen, testosterone, progesterone, and corticosteriods (cortisol) are all steroid hormones.

32. Sterols As Hormones “Designer steroids” are major sporting news where they have been used illegally in track and field, baseball, football and countless other sports. A heavily muscled Linford Christie who was disqualified from international competition after testing positive for a banned steroid.

34. Functions of Lipids Major components of cell membranes. Insulation. Protective covering. Energy storage – fat is stored in animal cells as large lipid droplets.

35. PROTEINS

36. Building Blocks AMINO ACIDS  Since proteins are LARGE molecules, they are composed of smaller building blocks – AMINO ACIDS. AMINO ACIDS

37. AMINO ACIDS (AA) There are only 20 different AA

38. AMINO ACID STRUCTURE R group is different in every AA

39. Observe different R groups

40. Models of Amino Acids CARBON OXYGEN HYDROGEN NITROGEN

41. PEPTIDE BONDS Amino acids are joined together by PEPTIDE BONDS. Bond forms between the –COOH (carboxyl) group of one AA and the -NH 2 of another AA. H H O H H O N C C OH + N C C OH N C C N C C+ H 2 O H R H R H R R OH PEPTIDE BOND

42. How Long Are Proteins? Proteins are long chains of amino acids with an average of 200 amino acids per chain.

43. PROTEIN Shapes

44. Hemoglobin Hemoglobin – a protein in red blood cells responsible for oxygen transport. Myoglobin Myoglobin – protein in muscles that serves as storage site for oxygen. EXAMPLES TERTIARY STRUCTURE QUATERNARY STRUCTURE

45. Functions of Proteins A. ENERGY SOURCE

46. B. STRUCTURAL COMPONENTS B. STRUCTURAL COMPONENTS Following are made out of proteins: HAIR TURTLE SHELL SPIDER WEB FEATHERS NAILS

47. Strands of the Protein Keratin Create Hair

48. C. FIGHT INFECTIONS Fibers antibodiesFibers in a blood clot and antibodies are made out of proteins.

49. D. ASSIST LIFE PROCESSES Transports oxygen in red blood cells. Aids digestion. Enzymes are proteins.

50. There are two kinds of nucleic acids, DNA and RNA. Both are involved in the storage and flow of information from gene to gene product. DNA Recently, we’ve learned that RNA also plays important regulatory roles. Nucleic Acids

51. Nucleotides Are the Monomers That Create Polymers of DNA and RNA

52. Nucleotides fuel the cell and coordinate its metabolism. Nucleotides are Important in Their Own Right ATP, the cell’s primary energy currency.

53. Molecules of Life Big Four Start with water, add lots of small carbon-containing molecules and ……. How do you build a cell? Use these four major classes of biological molecules.