Principles and Practice of Radiation Therapy Chapter 38 Breast Cancer Supplement: Male Breast Cancer Copyright © 2010 by Mosby, Inc., an affiliate of Elsevier Inc.

Male Breast Cancer General information Epidemiology Etiology Clinical presentation Detection and diagnosis Disease classification Treatment Survival

Male Breast Cancer Gynecomastia Age Causes Klinefelter’s syndrome

Epidemiology Incidence 2000 new cases Deaths 450 deaths Worldwide

Etiology Causes Risk factors BRCA2 BRCA1 Age Family history Gene mutation Klinefelter’s syndrome

Etiology Risk factors Radiation Alcohol Liver dysfunction Estrogen therapy Obesity Occupation

Clinical Presentation Lump Skin dimpling Nipple retraction Discharge

Detection and Diagnosis Should men be screened for breast cancer?

Detection and Diagnosis Types Adenocarcinomas Ductal carcinoma in situ (DCIS) Infiltrating ductal carcinoma (IDC) Lobular Paget’s disease of the nipple

Disease Classification Pattern of spread Nodes Site of metastases Staging TNM Same as female Estrogen receptor/progesterone receptor (ER/PR) HER2/neu

Treatment Surgery Chemotherapy Radiation therapy Mastectomy Sentinel node biopsy Chemotherapy Radiation therapy

Survival Five-year survival rates range from 30-85%