1. Risk Factors for Male Breast Cancer冯喆

3. GENETIC FACTORS OF MBC Family history of breast cancer Gene mutations
BRCA2 gene (lifetime risk——6% )
BRCA1 gene

4. ENDOCRINAL FACTORS OF MBC
Klinefelter syndrome
Liver disease
Obesity
Compared with other men, they have lower levels of androgens and more estrogens
XXY
Men with severe liver disease have relatively low levels of androgens and higher estrogen levels.
Prot.
Hormone
Obese men have higher levels of estrogens in their body.
Androgen
Fat cell
Estrogen

5. OTHER FACTORS OF MBC
Radiation
Age

6. PREVENTION OF MBC Maintaining an ideal body weight
Restricting alcohol consumption

7. CONCLUSION
Although certain risk factors may increase a man's chances of developing breast cancer,
the cause of most breast cancers in men is unknown.
For now, the best strategies for reducing the number of deaths caused by this disease are early detection and prompt treatment.

8. References
1.Brinton LA, Richesson DA, Gierach GL, Lacey JV Jr, Park Y, Hollenbeck AR, Schatzkin
A. Prospective evaluation of risk factors for male breast cancer. J Natl Cancer Inst. 2008
Oct 15;100(20):1477–1481. Epub 2008 Oct 7.
2.Fentiman IS, Fourquet A, Hortobagyi GN. Male breast cancer. Lancet. 2006;367:595–
604.
3. Giordano SH, Buzdar AU, Hortobagyi GN. Breast cancer in men. Ann Intern Med.
2002;137:678–687. 4. 5. 6.

9. Thank you!