Pancreatic cancer cell lines are sensitive to knockdown of outlier kinases. Pancreatic cancer cell lines are sensitive to knockdown of outlier kinases.

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Pancreatic cancer cell lines are sensitive to knockdown of outlier kinases. Pancreatic cancer cell lines are sensitive to knockdown of outlier kinases. Left, scatter plots display kinome profiles of select pancreatic cancer cell lines; kinases targeted for knockdown are shown in color (red, outliers; green, nonoutliers). Labels in black denote additional kinases with outlier expression. The growth curves display the effects of siRNA-mediated knockdown of sample-specific outliers (middle) and nonoutliers (right) for each cell line. Values represent mean ± SD. ****, P < 0.0001. Vishal Kothari et al. Cancer Discovery 2013;3:280-293 ©2013 by American Association for Cancer Research