1. Reduced expression of the tumor suppressor PTEN occurs in tumors with both squamous cell and adenocarcinoma histology.
Reduced expression of the tumor suppressor PTEN occurs in tumors with both squamous cell and adenocarcinoma histology. A, examples of PTEN IHC staining from representative NSCLC samples, ranging from total absence of PTEN in the tumor compartment (H-score 0), to PTEN expression in tumor cells equivalent to surrounding normal and stromal cells (H-score 300). B, scatter plot showing range of PTEN expression related to histology. Each point represents the H-score from a single tumor sample, grouped by histology. The horizontal line represents the mean H-score ± SE.
Jill M. Spoerke et al. Clin Cancer Res 2012;18:
©2012 by American Association for Cancer Research