Presentation is loading. Please wait.

Presentation is loading. Please wait.

Effect of miRNA mimic on platinum sensitivity.

Published byДаниил Голощанов Modified over 4 years ago

Similar presentations

Presentation on theme: "Effect of miRNA mimic on platinum sensitivity."— Presentation transcript:

1 Effect of miRNA mimic on platinum sensitivity.
Effect of miRNA mimic on platinum sensitivity. A, miR-193b* mimic effect on cellular sensitivity to carboplatin 24 hours posttransfection. Data shown in this figure is derived from a randomly selected LCL samples (GM07056). B, miR-193b* mimic effect on cellular sensitivity to cisplatin 24 hours posttransfection. Data shown in this figure is derived from a randomly selected LCL samples (GM07056). C, miR-193b* overexpression effect on carboplatin sensitivity in an OVCAR-3 cell line 48 hours posttransfection. Dash line represents the growth inhibition curve after transfecting cells with miR-193b* mimic, whereas the solid line represents the growth inhibition curve of the same cell line treated with a scramble control. A two-way ANOVA method was used to compare the cellular growth inhibition effect by platinum after treating the cells with either miR-193b* mimic or scramble control. Dana Ziliak et al. Mol Cancer Ther 2012;11: ©2012 by American Association for Cancer Research

Download ppt "Effect of miRNA mimic on platinum sensitivity."

Similar presentations

Suppl. Figure 1 A B Suppl. Figure 1. Relative (A) miR-21 and (B) miR-224 expression levels in HCC tumors in different stages (I,II,III,IV) assessed by.

Suppl. Figure 1 A B Suppl. Figure 1. Relative (A) miR-21 and (B) miR-224 expression levels in HCC tumors in different stages (I,II,III,IV) assessed by.
IDH1 mutant glioma cells are sensitive to TMZ

IDH1 mutant glioma cells are sensitive to TMZ
Strategies for differential inhibition of mTORC1 and mTORC2 with rapamycin. Strategies for differential inhibition of mTORC1 and mTORC2 with rapamycin.

Strategies for differential inhibition of mTORC1 and mTORC2 with rapamycin. Strategies for differential inhibition of mTORC1 and mTORC2 with rapamycin.
miR-133a positively regulated p53/p21 pathway.

miR-133a positively regulated p53/p21 pathway.
Antitumor activity of BAY in patient-derived tumor models.

Antitumor activity of BAY in patient-derived tumor models.
Effects of SC144 on in vivo ovarian tumor.

Effects of SC144 on in vivo ovarian tumor.
LNCaP * C4-2B Du145 22Rv1 SI Figure 1. miR-124 inhibits the proliferation of CaP cells. WST-1 cell proliferation analysis of AR-positive CaP cell lines.

LNCaP * C4-2B Du145 22Rv1 SI Figure 1. miR-124 inhibits the proliferation of CaP cells. WST-1 cell proliferation analysis of AR-positive CaP cell lines.
Bortezomib sensitivity correlates with basal NF-κB activity in KP lung adenocarcinoma cell lines. Bortezomib sensitivity correlates with basal NF-κB activity.

Bortezomib sensitivity correlates with basal NF-κB activity in KP lung adenocarcinoma cell lines. Bortezomib sensitivity correlates with basal NF-κB activity.
Inhibition of FGFR signaling and tumor growth in SNU-16 xenograft model by administration of E7090. Inhibition of FGFR signaling and tumor growth in SNU-16.

Inhibition of FGFR signaling and tumor growth in SNU-16 xenograft model by administration of E7090. Inhibition of FGFR signaling and tumor growth in SNU-16.
PDGFRβ is dispensable for EGFRvIII-driven GBM growth but is required for the optimal growth of EGFR-inhibited tumors. PDGFRβ is dispensable for EGFRvIII-driven.

PDGFRβ is dispensable for EGFRvIII-driven GBM growth but is required for the optimal growth of EGFR-inhibited tumors. PDGFRβ is dispensable for EGFRvIII-driven.
A20 inhibits caspase-8 cleavage and TRAIL-induced apoptosis.

A20 inhibits caspase-8 cleavage and TRAIL-induced apoptosis.
Dandan Wang et al. BTS 2018;3:350-362 miR-24 Regulates OGT and ATG4A to Play Cardioprotective Effects Sequence alignment of miR-24 targeting sites on OGT.

Dandan Wang et al. BTS 2018;3: miR-24 Regulates OGT and ATG4A to Play Cardioprotective Effects Sequence alignment of miR-24 targeting sites on OGT.
CCL5 is critical for the activity of CAFs and miR-CAFs.

CCL5 is critical for the activity of CAFs and miR-CAFs.
Signaling induced by BRAF L597R and L597S is sensitive to BRAF and MEK inhibitors. Signaling induced by BRAF L597R and L597S is sensitive to BRAF and MEK.

Signaling induced by BRAF L597R and L597S is sensitive to BRAF and MEK inhibitors. Signaling induced by BRAF L597R and L597S is sensitive to BRAF and MEK.
Fig. 2. Cellular response to FolamiRs in vitro.

Fig. 2. Cellular response to FolamiRs in vitro.
Effect of expression of constitutively active CAMKK2 on AMPK activation and the cell cycle in G361 cells. Effect of expression of constitutively active.

Effect of expression of constitutively active CAMKK2 on AMPK activation and the cell cycle in G361 cells. Effect of expression of constitutively active.
MMAE resistance and intracellular accumulation.

MMAE resistance and intracellular accumulation.
USP2a regulates MYC expression through the MDM2–p53 axis.

USP2a regulates MYC expression through the MDM2–p53 axis.
A, IC50 dose–response curves of SYD985, T-DM1, and ADC isotype control in all USC cell lines tested in vitro (i.e., HER2 3+ cell lines, P =

A, IC50 dose–response curves of SYD985, T-DM1, and ADC isotype control in all USC cell lines tested in vitro (i.e., HER2 3+ cell lines, P =
A, B, apoptosis analysis using Annexin V-FITC/PI was done on 5th, 7th, and 9th day after transfection either with si control or si AEBP1in U87MG and U138MG.

A, B, apoptosis analysis using Annexin V-FITC/PI was done on 5th, 7th, and 9th day after transfection either with si control or si AEBP1in U87MG and U138MG.

Similar presentations

Ads by Google