Figure 3 Nuclear-penetrating autoantibodies and synthetic lethality

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Figure 3 Nuclear-penetrating autoantibodies and synthetic lethality Figure 3 | Nuclear-penetrating autoantibodies and synthetic lethality. Nuclear-penetrating autoantibodies can inhibit DNA repair or directly damage DNA. In normal homology-directed repair (HDR)-proficient cells, this DNA damage can be repaired and the cells survive. Cancer cells that are HDR-deficient, however, cannot tolerate the accumulation of DNA double-strand breaks (DSBs) and ultimately die. The combination of these antibodies and HDR deficiency, therefore, leads to synthetic lethality. Noble, P. W. et al. (2016) DNA-damaging autoantibodies and cancer: the lupus butterfly theory Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.23