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Oh what a tangled web it weaves: BRCA1 and DNA decatenation

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Presentation on theme: "Oh what a tangled web it weaves: BRCA1 and DNA decatenation"— Presentation transcript:

1 Oh what a tangled web it weaves: BRCA1 and DNA decatenation
Alan Ashworth  Cancer Cell  Volume 8, Issue 2, Pages (August 2005) DOI: /j.ccr Copyright © 2005 Elsevier Inc. Terms and Conditions

2 Figure 1 Cell cycle-related functions of BRCA1
Double strand DNA breaks or arrested or collapsed replication forks occurring in S phase are repaired in part by BRCA1-dependent homologous recombination (Turner et al., 2005). BRCA1 acts in the intra-S and G2/M phase cell cycle checkpoints (Xu et al., 2001). BRCA1 is required for efficient decatenation of chromatids (Lou et al., 2005) and the checkpoint which monitors whether this has occurred (Deming et al., 2001). Cancer Cell 2005 8, 95-97DOI: ( /j.ccr ) Copyright © 2005 Elsevier Inc. Terms and Conditions

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