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Figure 5 Involvement of B cells in SLE

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1 Figure 5 Involvement of B cells in SLE
Figure 5 | Involvement of B cells in SLE. B cells are greatly influenced by the cytokine milieu and the type of T cell that derives from that cytokine milieu. In systemic lupus erythematosus (SLE), B cells interact with T follicular helper (TFH) cells at the T cell–B cell interface in secondary lymphoid organs. The interaction revolves around engagement of cell-surface receptors and secretion of cytokines. FcR, Fc receptor; mDC, myeloid dendritic cell; MHC, major histocompatibility complex; TCR, T-cell receptor; TH2, type 2 T helper cell; TLR, Toll-like receptor; Treg cell, regulatory T cell. Tsokos, G. C. et al. (2016) New insights into the immunopathogenesis of systemic lupus erythematosus Nat. Rev. Rheumatol. doi: /nrrheum

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