1. Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.132
Figure 3 Caspase 8 is required for normal M1 macrophage polarization in vitro
Figure 3 | Caspase 8 is required for normal M1 macrophage polarization in vitro. a | Following treatment with IFNγ and lipopolysaccharide (LPS) to induce M1 macrophage polarization in vitro, caspase 8 can block receptor interacting serine/threonine protein kinase 1 (RIPK1) signalling. b | In the absence of caspase 8, RIPK1 signalling proceeds unchecked, leading to an abnormal response in M1 macrophage polarization. c | Blockade of RIPK1 signalling, via chemical inhibition with necrostatin 1 (NEC1), restores normal M1 polarization of caspase 8-deficient macrophages. MYD88, myeloid differentiation primary response protein MYD88; TRIF, TIR domain-containing adapter protein inducing interferon-beta, also known as TICAM1.
Cuda, C. M. et al. (2016) The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases
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