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Figure 1 The current model of the pathogenesis of SLE

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Presentation on theme: "Figure 1 The current model of the pathogenesis of SLE"— Presentation transcript:

1 Figure 1 The current model of the pathogenesis of SLE
Figure 1 | The current model of the pathogenesis of SLE. The progression of systemic lupus erythematosus (SLE) can be divided into discrete stages. Environmental and genetic factors contribute to the development of disease. Triggers such as infection can elicit autoimmunity, but the elements that drive a sustained loss of tolerance and spreading of autoimmunity are poorly understood. Epigenetic changes, immune-complex deposition and autoantibody-mediated tissue damage can drive chronic inflammation and irreversible damage in end organs. IFN, interferon. Tsokos, G. C. et al. (2016) New insights into the immunopathogenesis of systemic lupus erythematosus Nat. Rev. Rheumatol. doi: /nrrheum

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CATEGORY: IMMUNE DYSFUNCTION Systemic Lupus Erythematosus (SLE) Angela Midgley, University of Liverpool, UK S YSTEMIC L UPUS E RYTHEMATOSUS © The copyright.

CATEGORY: IMMUNE DYSFUNCTION Systemic Lupus Erythematosus (SLE) Angela Midgley, University of Liverpool, UK S YSTEMIC L UPUS E RYTHEMATOSUS © The copyright.
Pathogenesis of systemic lupus erythematosus (SLE)

Pathogenesis of systemic lupus erythematosus (SLE)
Systemic Lupus Erythematosus (SLE)

Systemic Lupus Erythematosus (SLE)
Pathogenesis of systemic lupus erythematosus (SLE)

Pathogenesis of systemic lupus erythematosus (SLE)
Pathogenesis of systemic lupus erythematosus (SLE)

Pathogenesis of systemic lupus erythematosus (SLE)
Systemic Lupus Erythematosus

Systemic Lupus Erythematosus
Figure 3 The induction of anti-DNA antibodies by bacterial DNA

Figure 3 The induction of anti-DNA antibodies by bacterial DNA
Figure 1 Lymphocytes during the disease

Figure 1 Lymphocytes during the disease
Figure 1 Role of innate lymphoid cells (ILCs) in steady state,

Figure 1 Role of innate lymphoid cells (ILCs) in steady state,
Nat. Rev. Nephrol. doi: /nrneph

Nat. Rev. Nephrol. doi: /nrneph
of different experimental arthritis models

of different experimental arthritis models
Figure 3 The adaptive and maladaptive energy matrices

Figure 3 The adaptive and maladaptive energy matrices
Figure 5 Involvement of B cells in SLE

Figure 5 Involvement of B cells in SLE
Figure 1 Historical evolution of the clinical classification and

Figure 1 Historical evolution of the clinical classification and
Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.

Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 2 Proinflammatory mechanisms in CKD

Figure 2 Proinflammatory mechanisms in CKD
Figure 1 Factors underlying metabolic alterations in osteoarthritis

Figure 1 Factors underlying metabolic alterations in osteoarthritis
Figure 1 Induction of immune tolerance

Figure 1 Induction of immune tolerance
Figure 2 Risk factors for sarcopenia

Figure 2 Risk factors for sarcopenia

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