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Figure 3 Nucleic acid sensors in SLE

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Presentation on theme: "Figure 3 Nucleic acid sensors in SLE"— Presentation transcript:

1 Figure 3 Nucleic acid sensors in SLE
Figure 3 | Nucleic acid sensors in SLE. The importance of the immune response to nucleic acids in systemic lupus erythematosus (SLE) has been emphasized by data from mouse models and patients with monogenic diseases associated with defects in these pathways. Toll-like receptors (TLRs) are restricted to vesicles and primarily respond to endocytosed nucleic acids. Cytoplasmic sensors recognize endogenous nucleic acids as well as a myriad of viruses. Responses converge on two transcription factors, interferon regulatory factor 3 (IRF3) and nuclear factor-κB (NF-κB), which are responsible for the induction of type I interferon (IFN) expression as well as some inflammatory cytokines. Tsokos, G. C. et al. (2016) New insights into the immunopathogenesis of systemic lupus erythematosus Nat. Rev. Rheumatol. doi: /nrrheum

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