Figure 1 Metabolic profiling as a tool for studying rheumatic diseases

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Figure 1 Metabolic profiling as a tool for studying rheumatic diseases Figure 1 | Metabolic profiling as a tool for studying rheumatic diseases. The metabolites in circulation or found in tissues not only reflect the genetic background and the gene expression profile of an individual, but also their lifestyle, diet, medication use and any ongoing pathogenic processes. Integrating metabolic and genetic profiling can help to differentiate between molecular changes observed in patients with rheumatic diseases that are derived from modifiable factors (dynamic changes that respond to diet or medication), and those that are directly linked to an individual's genetic profile. Metabolomics could also monitor the progression of a disease or treatment. Menni, C. et al. (2017) Mixing omics: combining genetics and metabolomics to study rheumatic diseases Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.5