LIAISON®: Instrument Overview

Contents Highlights Hardware overview User interface Main features The Diagnostic Specialist Contents Highlights Main features Samples and Reagents Accessories Hardware overview User interface L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

LIAISON®: Main features The Diagnostic Specialist LIAISON®: Main features L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

LIAISON®: Main features “Flash” chemiluminescence detection system Paramagnetic microparticle solid phase Continuous loading of samples and reagents Random access or batch mode 2-point calibration (stability up to 4 weeks) Auto-dilution, auto-reflex, STAT Maximum throughput: ~180 results/h L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

LIAISON®: Samples and reagents The Diagnostic Specialist LIAISON®: Samples and reagents L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Sample management Continuous loading of sample racks LIAISON®: Samples and reagents Sample management Continuous loading of sample racks On board capability: 144 samples Active opening flap Barcode recognition of racks and samples (compatibility with different tube diameter) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Integral label with barcode LIAISON®: Samples and reagents Reagents (1) Reagent Integral: typical layout Magnetic Particles Other Reagents Handle Calibrators Holder Aluminum Seals Nose Stirring wheel Integral label with barcode L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Reagents (2) Kit configuration: Reagent Integral LIAISON®: Samples and reagents Reagents (2) Kit configuration: Reagent Integral mini-CD (IFU, method file) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Reagents (3) On board capability: 15 integrals (1500 tests) LIAISON®: Samples and reagents Reagents (3) On board capability: 15 integrals (1500 tests) Continuous loading of “reagent integrals” (recognition via barcode) On board refrigerated area (on-board stability up to 8 weeks) Active opening flap L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

LIAISON®: Samples and reagents LIAISON® Controls Characteristics and control run requirements are dependent on assays QC software L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

LIAISON® Accessories The Diagnostic Specialist L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Wash/System Liquid Supplied as concentrated LIAISON® Accessories Wash/System Liquid Supplied as concentrated 1L  9L with distilled/deionized water Water quality requirement: “NCCLS grade III” Inventory controlled by sensor 1 liter 10 liters L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Starter Reagents Starter 1, Starter 2 Primary bottles on board LIAISON® Accessories Starter Reagents Starter 1, Starter 2 Primary bottles on board Inventory controlled by sensors L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Reaction modules Continuous loading Inventory controlled by sensors LIAISON® Accessories Reaction modules Continuous loading 1 reaction module = 6 cavities (6 tests) stacker capacity = 120 reaction modules (720 tests) Inventory controlled by sensors L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Light Check Required for“System Test” “SYSTEM TEST”: LIAISON® Accessories Light Check Required for“System Test” “SYSTEM TEST”: (daily pre-routine check) Priming Checking of pipetting accuracy and precision Checking of signal background and level L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Solid waste bag Collector of disposed (emptied) Reaction Modules LIAISON® Accessories Solid waste bag Collector of disposed (emptied) Reaction Modules Level controlled by software counter L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Cleaning Kit CLEAN Tool PUMP Tool LIAISON® Accessories Cleaning Kit CLEAN Tool For weekly (daily) customer maintenance procedure (automated CLEAN test) PUMP Tool For monthly customer maintenance procedure L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

LIAISON®: hardware overview The Diagnostic Specialist LIAISON®: hardware overview L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Instrument tour LIAISON®: hardware overview L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Instrument tour Left pipettor Right pipettor 2 pipetting needles LIAISON®: hardware overview Instrument tour Left pipettor (samples, calibrators) Right pipettor (reagents) 2 pipetting needles (Teflon coated; internal and external programmable wash) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Instrument tour LIAISON®: hardware overview L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

(housing for Reaction Modules) LIAISON®: hardware overview Instrument tour Stacker (housing for Reaction Modules) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

(housing for Starter 1 and Starter 2) LIAISON®: hardware overview Instrument tour Starter box (housing for Starter 1 and Starter 2) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

LIAISON®: hardware overview Instrument tour Sample area (fits 12 sample racks, each rack has 12 available positions) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Instrument tour Reagent area (15 lanes, refrigerated) LIAISON®: hardware overview Instrument tour Reagent area (15 lanes, refrigerated) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

(3 areas accessible by the pipettors) LIAISON®: hardware overview Instrument tour Pipetting areas (3 areas accessible by the pipettors) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

(for internal/external wash) LIAISON®: hardware overview Instrument tour Needle wash stations (for internal/external wash) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Incubator (36±1°C, 16 slots, one reaction module each) LIAISON®: hardware overview Instrument tour Incubator (36±1°C, 16 slots, one reaction module each) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Washer (3 needles, in magnetic field) LIAISON®: hardware overview Instrument tour Washer (3 needles, in magnetic field) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Measure chamber (Starter injection; measure) LIAISON®: hardware overview Instrument tour Measure chamber (Starter injection; measure) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

(emptied reaction modules) LIAISON®: hardware overview Instrument tour Solid waste (emptied reaction modules) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Instrument tour Wash/System liquid Wash/System liquid LIAISON®: hardware overview Instrument tour Wash/System liquid (2x10L, Double tank, sensor-controlled) Wash/System liquid (10L, sensor-controlled) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

(10L, sensor-controlled) LIAISON®: hardware overview Instrument tour Liquid waste (10L, sensor-controlled) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

Reaction Modules from stacker to waste LIAISON®: hardware overview Reaction Modules from stacker to waste Meas. Wash Pip. Inc. Pip. Waste Staker L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

LIAISON® User Interface The Diagnostic Specialist LIAISON® User Interface L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

General characteristics LIAISON®: User Interface General characteristics Touch screen monitor Easy and intuitive menu-structured software Multi-language Sample result traceability (kit info, flags, etc.) Access-right structure Flexible LIS connection L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview

References User Manual (multi-language) Quick Guide (multi-language) LIAISON®: User Interface References User Manual (multi-language) Quick Guide (multi-language) L-CS-304-P (081222) (Rev. A) Liaison - Instrument Overview