ISGO: The International Structural Genomics Organization Goals of ISGO Develop standards and policies for structural genomics Sponsor international meetings and workshops Promote cooperation in structural genomics, including between public and private efforts Promote deposition of coordinates, raw data, and other information

ISGO Led by John Moult, Chris Sander, John Norvell, Barbara Skene Workshops on international cooperation Hinxton (April, 2000) and Airlie House (April, 2001) Task Forces Task Force on Deposition, Archiving, and Curation of the Primary Information (Helen Berman and Geoff Barton, chairs) Task Force on Mechanisms for Publication and Recording of Methods and Results (Guy Dodson, chair) Task force on Intellectual Property (John Norvell, Barbara Skene, chairs) Task Force on Numerical Criteria in Structural Genomics (Randy Read, chair) Task Force on Target Tracking (Steve Bryant, chair) Workshops on in vitro expression systems (Shigeyuki Yokoyama)

ISGO Agreed Principles and Procedures Coordination of International Programs in Structural Genomics “The goal is to encourage harmonious cooperation among a broad range of public and private sector institutions in the international effort to characterize macromolecular structures in living organisms on a pan-genomic scale” Key Principles Free exchange of data and materials Deposition of coordinates and other mandatory data in the PDB immediately on completion of structure determination Public release in a short time (always less than 6 months) Open exchange of target information

ISGO Additional recommendations Short peer-reviewed papers to ensure quality (Proteins, Structure Function and Genetics; Acta Cryst. D in place now) Quality is not to be sacrificed in the interests of quantity Structure depositions will be accompanied by experimental data Access to material such as clones, cell lines, and protein samples encouraged Exchange of protocols and materials encouraged (Clearinghouse recommended) Promote the free access and exchange of scientific information among scientists engaged in basic research. Harmonize patent law. Strengthen the utility requirement for patentability. ( Community is concerned about the implications of the granting of patents based solely on the submission of three-dimensional structural co-ordinates, without any identified non-trivial utility.)

ISGO Today Open membership mailing list Web site: An executive committee Continuing members: Shigeyuki Yokoyama, Udo Heinemann, Tom Terwilliger New members: Seiki Kuramitsu, Ian Wilson, David Stuart An Advisory Board Gaetano Montelione, Guy Dodson, Chris Sander, Dino Moras, Joel Sussman, Wayne Hendrickson, John Norvell, Barbara Skene, Norihisa Hara Active Task forces Task Force on Deposition, Archiving, and Curation of the Primary Information (Helen Berman, chair) Task Force on Mechanisms for Publication and Recording of Methods and Results (Guy Dodson, chair) Task force on Intellectual Property (John Norvell, Barbara Skene, chairs)

ISGO and the Structural Genomics Community Sponsored International Conference on Structural Genomics in Berlin, Oct , 2002 (Udo Heinemann, organizer) Sponsored workshops for collaborative efforts and sharing of technology in vitro expression workshops ( , Shigeyuki Yokoyama) Collaboration in high-throughput crystallography (March 2002, Tom Terwilliger) Automation of X-ray Structure Determination of Macromolecules (Oct, 2002, Uwe Mueller) Run pre-conference ISGO session on structural genomics policies (Oct, 2002) Sponsoring next International Conference on Structural Genomics (USA, 2004/2005 (Gaetano Montelione & Tom Terwilliger have volunteered to organize)

Suggested ISGO statement on patentability of protein structures “ISGO strongly supports the position that a high level of utility should be required for patenting of protein structures” NOTE: ISGO continues to expect that most structures will be immediately deposited and released, as agreed at Airlie House.

Continued work of Task Forces Task Force on Deposition, Archiving, and Curation of the Primary Information. (Helen Berman, chair) Development of data dictionary for deposition of all relevant experimental data (cloning, protein production, crystallography, NMR) Development of target tracking web site and structural genomics pipeline for deposition to PDB Task Force on Mechanisms for Publication and Recording of Methods and Results (Guy Dodson, chair) Negotiate with journals to create a smooth pathway for publishing short structure reports (Identify what should be in short articles) Task force on Intellectual Property (John Norvell and Barbara Skene) Discussion and drafting of proposed policies on patenting and structural genomics