1. Structural Genomics, ISGO, and Structural Genomics Task Forces Open ISGO Structural Genomics Task Force Meeting ISGO International Structural Genomics Conference Berlin, 10 October 2002 Udo Heinemann (MDC, Berlin)

2. Structural Genomics A large-scale project to determine the three-dimensional shapes of all proteins and other important biomolecules encoded by the genomes of key organisms Definition phrased at the April 2001 Second International Structural Genomics Meeting, Airlie House, VA, USA

3. Structural Genomics The Structural Genomics Project aims at determination of the 3D structure of all proteins. This aim can be achieved in four steps: Organize known protein sequences into families. Select family representatives as targets. Solve the 3D structure of targets by X-ray crystallography or NMR spectroscopy. Build models for other proteins by homology to solved 3D structures. http://www.structuralgenomics.org/main.html

4. A Brief History of Structural Genomics 1995SG project proposed in Japan 1997 Apr.SG pilot project starts at RIKEN Inst. 1997SG studies initiated through DOE, NIGMS in US 1998/99Initial SG projects start in Canada, Germany, US 1999 JuneCall for SG pilot projects issued by NIGMS/NIH 2000 Jan.OECD Committee for Scientific and Technological Policy (CSTP) proposes to initiate SG studies 2000 Apr.1 st International SG Meeting, Hinxton, UK 2000 JuneOECD/Global Science Forum (GSF) and SG Workshop, Florence, Italy 2000 Sep.SG: From Gene to Structure to Function, Cambridge, UK 2000 Sep.NIGMS Protein Structure Initiative starts in US with 7 Centers 2000 Nov.International Conference on SG (ICSG 2000), Yokohama, Japan / International SG Task Force Meeting / OECD/GSF Meeting 2001 Jan.OECD/CSTP/GSF, Paris, France – Further Study on SG 2001 Apr.2nd International SG Meeting, Airlie House, US – Start of ISGO 2001 Sep.NIGMS Protein Structure Initiative adds 2 new centers 2002 Mar.European Commission announces funding of Structural Proteomics in Europe (SPINE) 2002 Apr.National project on Protein Structural and Functional Analyses starts in Japan 2002 Oct.ISGO International Conference on SG (ICSG 2002), Berlin, Germany

5. Projects Taken from www.isgo.org Ontario Centre for SG Montreal-Kingston Bacterial SG Initiative Montreal Network for Pharmaco-Proteomics and SG CyberCell Project Structural Proteomics in Europe (SPINE) SG of Mycobacterium pathogens SG of Eukaryotes Yeast SG SG of Orphan E. coli Genes Protein Structure Factory RIKEN SG/Proteomics Initiative National Project on Protein Structural and Functional Analyses (7 centers) Biological Information Research Center (BIRC) The Korean Structural Proteomics Research Organization National Centers for Competence in Research (NCCR) North West SG Centre Oxford Protein Production Facility Cambridge Group New York SG Research Consortium Midwest Center for SG Berkeley SG Center Northeast SG Consortium TB SG Consortium Southeast Collaboratory for SG Joint Center for SG SG of Pathogenic Protozoa Consortium Center for Eukaryotic SG Structure 2 Function Project Canada Europe France Germany Japan Korea Switzerland UK USA

6. Structural Genomics Structural Genomics: A large- scale project to determine the three-dimensional shapes of all proteins and other important biomolecules encoded by the genomes of key organisms SG is genome-driven, aims at completeness SG needs high throughput, automation SG needs international coordination to foster cooperation and avoid waste of resources

7. International Coordination www.proteinstrukturfabrik.de International agreements The projects make their structure analysis targets public (Target Tracking) The projects grant mutual technical help Protein structures from structural genomics projects must meet stringent quality criteria The structures are published in a timely manner Deriving utility from protein structures is not excluded

8. The International Structural Genomics Organisation (ISGO) Initiated at Airlie House Meeting (2001) Activities International coordination (task forces) Workshops, meetings Conferences Appointed officers Udo Heinemann (Germany / Europe) Tom Terwilliger (USA / North America) Shigeyuki Yokoyama (Japan / Asia)

9. Structural Genomics Taskforces Informatics (J. Moult, U. Maryland, USA) Numerical Criteria for Evaluating and Assuring Structure Quality (R. Read, U. Cambridge, UK) Tracking and Registra- tion of Targets (S. Bryant, NIH, Bethesda, USA) Deposition, Archiving, and Curation of the Primary Information (H. Berman, Rutgers U., USA) Mechanisms for Publication and Recording of Methods (G. Dodson, U. York, UK) Intellectual Property (B. Skene, Wellcome Trust, UK, and J. Norvell, NIGMS, USA)