Lesson 2.1.2 Avery

The Insulin Glucose Connection Introduction: The building blocks for our body are cells Cells are able to communicate by different molecules that move from cell to cell The molecules that are used are called proteins The protein is released from one cell and sent to another cell. They attach at receptors

Goals of the Lesson To differentiate between a credible/non-credible source Use the internet to research the connection between Insulin and Glucose. Write a summary on the process of insulin binding to the cell to accept glucose Using credible sources research key terms and their connection Research similarities and differences between Type 1 and 2 with regards to how the body uses insulin Create a 3D model that represents how the body gets glucose into the cell with type one and type two diabetes.

Credible Sources To tell if a website is credible or not use the following chart to check. Credible Not Credible Author Establishes credibility on the topic (degrees, experience) No information on the author Website/Url A credible website (gov site, university, charity) People can change the information and give false info (Wiki) Ad’s Little to no pop ups or ads A lot of pop-ups and ads Date Has a recent or newer copyright date Old/out of date,old information Reference Has references and additional links No references

Summary of Insulin and Glucose The digestive system breaks down food that was eaten to simple glucose molecules Glucose enters the bloodstream and flows through the pancreas The pancreas releases insulin into the bloodstream The glucose arrives at the cell but can’t get into the cell without the insulin The insulin arrives and attaches itself to the insulin receptor on the outside of the cell membrane The insulin receptor triggers glut4 transporters to travel to the inside of the cell membrane to open up part of the cell membrane for the glucose to come in Cell can use glucose to make energy

Key Terms Insulin: Hormone produced in the pancreas that is used by the body to let glucose into the cell Glucose: Sugar that is found in food that the is used by the cells as a form of energy Beta Cells: Specialized cells in the pancreas that release insulin as blood glucose levels increase Glut 4 Transporters: Transport protein inside a cell that is triggered by the insulin receptor to attach to the cell membrane and open it up to for the glucose Insulin Receptor: A receptor that sits on the outside of the membrane and is the place where insulin attaches to release glut4 Blood: In reference to diabetes the blood carries glucose and insulin to different cells and different parts in the body. Lymph: The lymph in the body can attack insulin causing the body to not get enough glucose into the cells Cell Membrane: Outer layer of the cell that is semi-permeable and regulates what comes in and goes out of the cell

Similarities Between Type 1&2 Is detected in youth Have similar symptoms Detected in later years Body doesn’t produce insulin Failure to produce proper insulin Produces insulin that gets rejected by the cells Insulin injections are used as a mediation Insulin is a treatment Can be regulated with healthy exercise and diet

3D Model Last part of the lesson was to create a 3D moveable model that shows how a person with diabetes’ body’s relationship between insulin and glucose. The model needs to be simple and easy enough to understand, like you were going to give a presentation to people who were recently diagnosed with type 1 or 2 diabetes. The presentation must have included all of the key terms and how the work within the body. It must be easy to understand for people who have no prior knowledge on the disease.