Cellular Basis of Learning and Memory

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Cellular Basis of Learning and Memory BIPN 148 Spring 2006 April 3-June 9, 2006 This course will examine the cellular and molecular mechanisms that underlie learning and memory. Topics covered will include the role of the hippocampus in learning and memory, neurotransmitter systems and receptors involved in learning and memory, and biochemical mechanisms of synaptic plasticity. Emphasis will be placed on discussing experiments from the primary literature. A solid background in cell and molecular biology is expected. Prerequisites: BILD 1; BILD 2; BIBC 100/102; BIPN140 highly recommended. Times: MWF at 4:00 Location: CSB 001 Web Site: http://www.biology.ucsd.edu/classes/bipn148.SP06/ Recommended Text Ghosh and Scanziani Lecture Notes Lecture notes are available for purchase through University Readers at http://www.universityreaders.com/students Grading: Weekly Quizzes: 30% Group paper and presentation: 30% Final Exam: 40% Grading is on a curve. Discussion Sessions/TA office hours (optional): Pacific Hall 1115 Wednesdays at 5:00 Fridays at 3:00 Contact Information Professors: Anirvan Ghosh, Pacific Hall 1123, aghosh@ucsd.edu, 822 4142. Massimo Scanziani, CMG 2nd Floor, massimo@ucsd.edu, 822 3839 TEACHING ASSISTANTS: Will Barkis (wbarkis@ucsd.edu) and Mark Chen (m10chen@ucsd.edu)

Subdivisions of Human Memory DECLARATIVE (EXPLICIT) NONDECLARATIVE (IMPLICIT) FACTS EVENTS PROCEDURAL (SKILLS AND HABITS) PRIMING SIMPLE CLASSICAL CONDITIONING NONASSOCIATIVE LEARNING EMOTIONAL RESPONSES SKELETAL MUSCULATURE MEDIAL TEMPORAL LOBE STRIATUM NEOCORTEX AMYGDALA CEREBELLUM REFLEX PATHWAYS Milner B, Squire LR, Kandel ER: "Cognitive neuroscience and the study of memory". Neuron 1998, 20:445-468.

Classical Conditioning (an example of implicit memory) Ivan Pavlov

Implicit Memory: Pavlovian Associative Conditioning Conditioned Stimulus Unconditioned Response

Implicit Memory: Fear Conditioning TRAINING CONTEXTUAL TEST CUED TEST Animal is placed in novel context Hears a tone Receives foot shock Animal is returned to same context Test for freezing behavior Animal is placed in modified context

Implicit memory: Conditioned Taste Aversion DAY 1 B 1.0 1st Exposure to Food Item 0.8 0.6 grams blueberry bar 0.4 Injection of LiCl or NaCl 0.2 DAY 2 0.0 LiCl NaCl Grams Ingested on 2nd Exposure (LiCl treated group compared to NaCl treated control) 2nd Exposure to Food Item

Implicit Memory: Neophobia DAY 1 1st Exposure to Food Item 0.0 0.2 0.4 0.6 0.8 1st intake 2nd intake grams blueberry bar DAY 2 2nd Exposure to Food Item Grams Ingested (1st exposure compared to second exposure)

(Distinction between short-term Hermann Ebbinghaus (Distinction between short-term and long term memory)

Ebbinghaus Test ZOG MIF XEL RIC DAJ NEQ SOR YAN QIJ GEB Memorize this set of words ZOG MIF XEL RIC DAJ NEQ SOR YAN QIJ GEB

(keep the words in mind!) Wait for 1 minute (keep the words in mind!)

Write down the words in sequence Did anyone get all 10 right?

By testing subjects after various delays Ebbinghaus developed the concept of short-term and long term memory Sensory Information Working Memory/Short term Memory (Minutes) Long Term Memory (Hours/Days/Years)

Working Memory Requires Frontal Lobe Function neuro3e-fig-01-12-3.jpg

Declarative Memory Required the Hippocampus neuro3e-fig-01-12-4.jpg

neuro3e-fig-01-12-6.jpg