Presentation of successful Marie Curie projects FP7–PEOPLE–2009–IEF FP7–PEOPLE–2012–CIG Robert Vianello Division of Organic Chemistry and Biochemistry Ruđer Bošković Institute, Zagreb, Croatia robert.vianello@irb.hr

• 60.000 Marie Curie fellows since the launch of the Action in 1996 • over 10.000 doctorates supported • Marie Curie fellows originate from all over the World (130 nationalities) • host institutions in Marie Curie actions are located in more than 70 countries • 46% researchers remain in Europe after IIF Marie Curie fellowships • women participation in Marie Curie actions equals 38% (close to desired 40%)

Marie Skłodowska-Curie Actions excellent researchers’ training and mobility for career development

Number of projects in Marie Curie actions (2007–2012)

Category of researchers Intra-European Fellowships (IEF) - FACTS • Budget: 95.000.000 EUR (2009) • Highly competitive • 2008: 75.000.000 EUR for around 440 fellowships / 1.763 applications (25.0%) • Basic documents: Guide for Applicants (65 pages) PEOPLE 2009 Work Programme (52 pages) 134.000.000 EUR (2013) (83 pages) (70 pages) Category of researchers EUR per year (2009) < 4 years of experience 35.300 4–10 years of experience 54.300 > 10 years of experience 81.400 EUR per year (2013) 38.000 58.500 87.500

Personal motifs to apply • Quality of the fellowship - enables high–quality scientific work - promotes acquisition of new competencies (Career Development) • Assure financing after the termination of the domestic UKF grant - 3A project (“My first research grant”) 01/09/2008 – 31/08/2010 - “Computational Prediction of Structure and Catalytic Activity of New Organic Superacids” - co-financed by the industrial partner APO Ltd. Zagreb • Many years of acquaintance with the host scientist and the host institution - 3 bilateral Croatian–Slovenian projects, 1 joint scientific paper • Close vicinity to Zagreb

National Institute of Chemistry Host institution National Institute of Chemistry • Founded in the year 1946 - leading reasearch institute in Slovenia in the field of chemistry and related sciences - independent, non–profit, public research institute - 273 employees (31/12/2009), of which around 243 carry out research work (114 with doctorates) in 15 laboratories and 2 infrastructure centers • Research on structure, properties and function of biologically relevant systems - Laboratory for Biosynthesis and Biotransformation / Laboratory of Biomolecular Structure (vibrational spectroscopy) / Slovenian NMR centre - Laboratory for Biocomputing and Bioinformatics / Laboratory for molecular modeling / Laboratory of chemometrics • Publish around 200 scientific papers annually - average 2007 Impact Factor = 2.7

National Institute of Chemistry Host institution National Institute of Chemistry • Diverse network of partners from the industry - Krka, Lek, Helios, Belinka, Renault, Kolpa, Dior, BASF - 20% of the annual income of the institute • Branched network of international collaborations - bilateral projects (30–35 / year): EU, USA, Japan... - multilateral projects (20–25 / year): Joule, Phare, Tempus, Eureka, COST... - 15 FP5 projects - 14 FP6 projects - total financial value of all FP5 and FP6 projects: 5.000.000 EUR • Adequate infrastructure - VRANA (eng. crow) cluster of PC computers with 772 processors (2008)

Host scientist Dr. Janez Mavri • Senior research associate and a leader of the Laboratory for Biocomputing and Bioinformatics, and Associate professor at the Faculty of Pharmacy in Ljubljana • Research interests: dynamics of enzyme reactions, investigation of systems connected through hydrogen bonds, chemical reactivity in solutions • Published 68 scientific papers and 7 book chapters - total number of citations = 766; Hirsch index = 16 (08/2009) - plenary lecture at the Gordon conference “Isotopes in Biology and Chemistry” (Ventura, California, USA; 2006) - 2 invited lectures and more than 70 oral presentations at international conferences and foreign universities

Host scientist Dr. Janez Mavri • Guest Professor at the Franche–Comte University (Besancon, France) 2003. - “Biomolecular simulations” at undergraduate level • French Long Term Human Frontier Science Program Fellowship (University of Groningen, Netherlands) 1993–1995 • Senior Fulbright Scholarship (University Southern California, USA) 2004 • In the last 3 years: mentor of 3 undergraduate and 3 postgraduate students • In the last 3 years: mentor of 2 postdoctorate students during a 1 year stay at NIC

Project application • Topics of research were chosen by the host–scientist taking into account competencies and interests of the fellow • The host–scientist helped choosing references for the proposal writing • Formal parts of the application are trivial (Part A) • Research project is much more serious (Part B) - take particular care about every detail written in the Guide for Applicants • We did not select any reviewers for our proposal

Contents and goals of the project Computational Studies of Proton Dynamics in Hydrogen Bonded Systems and Enzymes (CoSProDyn) • Improve understanding of the biocatalysis and receptor triggering by studying quantum nature of proton in proteins • Research will be oriented towards 3 biological systems using state– of–the–art methods of the computational biochemistry • duration of the project: 18 months • total financial value: 99.127,60 € • beginning date: 1st October 2010

Structure of the project application (Part B) maximum 8 pages maximum 2 pages maximum 7 pages maximum 6 pages maximum 4 pages

Structure of the project application (Part B) – HORIZON 2020

Project budget • project duration: 18 months Living Allowance: 54.300 € x 1,5 x 0,808 65.811,60 € Travel Allowance: 250 € x 2 times 500,00 € Mobility Allowance: 800 € x 18 months x 0,808 11.635,20 € Career Exploratory Allowance: 2.000 € 2.000,00 € Participation Expenses: 500 € x 18 months 9.000,00 € Overheads and Managment: 700 € x 18 months x 0,808 10.180,80 € ------------------------------------------------------------------------------------------------------------- TOTAL FINANCIAL VALUE 99.127,60 € Hungary (0,665): 83.619,25 € Denmark (1,335): 156.280,75 €

Chronology of events 08/2009 Registration to EPSS online system 18/08/2009 Application submitted through EPSS online system The number IEF–255038 was awarded 20/08/2009 Formal Acknowledgement of Receipt received 25/11/2009 Evaluation Summary Report received Total number of applications: 2.398 Number of proposals above thresholds: 1.857 (77.4 %) Budget: 95.000.000,00 € Requested funds: 323.922.519,80 € (340,9 %)

Evaluation Summary Report

Evaluation Summary Report

Evaluation Summary Report

Evaluation Summary Report

Chronology of events 08/2009 Registration to EPSS online system 18/08/2009 Application submitted through EPSS online system The number IEF–255038 was awarded 20/08/2009 Formal Acknowledgement of Receipt received 25/11/2009 Evaluation Summary Report received 22/12/2009 Invitation to Negotiate received A category: 575 (24.0 %) Total number of applications: 2.398 B category: 174 (7.3 %) C category: 1.108 (46.2 %) Number of withdrawn projects: 10 (0.4 %) D category: 531 (22.1 %) E category: 0 (0.0 %)

Reminder (240.500.000 €) H2020-MSCA-IF-2014 www.NEWFELPRO.hr 12.03.2014. Publication of call 11.09.2014. 17:00:00 Brussels time Deadline for submission of proposals end of December 2014 Evaluation Summary Reports January 2015 Invitation to Negotiate from March 2015 Signature of first Grant Agreements 03.10.2014. 31.12.2014. 16:00 CET end of March 2015 April 2015 From May 2015

Contents and goals of the project (FP7–PEOPLE–2012–CIG) Computational Studies of the Biogenic Amines of the Brain for Targeting Neurological Diseases (CompBAND) • Improve the understanding of a relation between features, metabolic pathways and signal transduction of amine neurotransmitters and the treatment of neurological diseases • Research will be oriented towards 2 biological systems using state–of–the–art methods of the computational biochemistry • duration of the project: 48 months • total financial value: 100.000 EUR • beginning date: 1st April 2013

Evaluation Summary Report

Evaluation Summary Report

Evaluation Summary Report

Dopamine synthesis and metabolism by monoamine oxidase enzymes (MAOs) reproduced from: MBH Youdim, DE Edmondson, KF Tipton, Nature Rev Neurosci 2006, 7, 295. Patients with neurological diseases: Increased level of MAO activity Concentrations of dopamine close to zero

R Borštnar, M Repič, M Kržan, J Mavri, R Vianello Eur J Org Chem 2011, 6419–6433. R Vianello, M Repič, J Mavri Eur J Org Chem 2012, 7057–7065.

50.000th Marie Curie Fellowship Award

"EU FP7 People Specific Programme Success Stories Booklet"

Official site of the European Commission (www.croatia-in-the-eu.eu)

http://ec.europa.eu/programmes/horizon2020/

Intra-European Fellowships for career development (IEF) FP7 Marie Curie Actions Intra-European Fellowships for career development (IEF) At various stages of their career, experienced researchers may welcome an opportunity to acquire new research skills or experience working in other sectors. Marie Curie Intra-European Fellowships for Career Development specifically aim at helping experienced researchers to try something new for a while. Who can apply? Researchers can be of any nationality but as a general rule must move from one Member State or Associated country to another in order to carry out the project. You must have either a doctoral degree or at least 4 years’ full-time equivalent research experience, after obtaining a degree permitting you to embark on a doctorate. What does the funding cover? Financial support is provided for a period of 12-24 months (full-time equivalent), for individual projects presented by experienced researchers from Member States or Associated Countries in liaison with a host organisation from a Member State or Associated Country.

Office for international projects, RBI National Institute of Chemistry Renata Slovinić Ines Ječmenjak Marijana Klasnić–Kožar Vesna Kotarski Višnja Petera Suzana Karabaić, PEOPLE NCP, Croatia National Institute of Chemistry Janez Mavri Meta Skumavc Marijana Novič Marjetka Podobnik Rada Drnovšek Radojka Verčko, PEOPLE NCP, Slovenia