LRH-1 controls cell proliferation in antiestrogen-sensitive and antiestrogen-resistant breast cancer. LRH-1 controls cell proliferation in antiestrogen-sensitive.

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LRH-1 controls cell proliferation in antiestrogen-sensitive and antiestrogen-resistant breast cancer. LRH-1 controls cell proliferation in antiestrogen-sensitive and antiestrogen-resistant breast cancer. A, GO analysis of LRH-1–bound genes associated with strong or weak FAIRE and H3K27ac signal. B proliferation assays of MCF7, LCC2, and LCC9 following LRH-1 depletion with effective shLRH-1 in presence or not of tamoxifen (TAM) or ICI treatment. Each point represents the mean + SEM for three independent biologic replicates. Stéphanie Bianco et al. Cancer Res 2014;74:2015-2025 ©2014 by American Association for Cancer Research