1. A, RT-PCR expression of matriptase-1 and matriptase-2 in a variety of 24 human cell lines.
A, RT-PCR expression of matriptase-1 and matriptase-2 in a variety of 24 human cell lines. The expression of matriptase-2 mRNA was assessed (and reassessed) in a panel of human cell lines. Matriptase-2 was only expressed in a few breast cancer cells and in the liver cancer cell line. B, matriptase-2 protein expression in human cell lines. Western blotting was used to confirm the results observed through RT-PCR. The matriptase-2 protein was found to be expressed in the MCF7 and ZR-751 breast cancer cell lines, which had a low invasive nature. In addition, matriptase-2 was also expressed by the PLC-PRF-5 liver cancer cell line and the HRT-18 colorectal cancer cell line.
Christian Parr et al. Clin Cancer Res 2007;13:
©2007 by American Association for Cancer Research