Zirconia – Alumina – Metal Primer

BISCO’s Z-PRIME Plus is a single-component priming agent used to create adhesion between indirect restorative materials and all resin containing cements.

Z-PRIME Plus - A proprietary Formula of concentrated MDP/Carboxylate monomers has been specifically formulated to address the current weakness in competitor’s primers and create a compelling reason to replace them immediately!

Bisco Products v.s. Zirconia/Silane Competitors Product Applications Components Z-PRIME™ Plus Bisco Zirconia, Alumina, Metal Silica-ceramics Zirconia, Alumina, Metal, Silica-ceramics BPDM, Phosphate, Ethanol Silane Phosphate, Silane* Porcelain Primer Bisco Monobond Plus Ivoclar Vivadent Clearfil Ceramic Kuraray *: Silane is not stable in the presence of acidic phosphate monomer.

Issue of Silane Incorporation into Zirconia Primers Silane Primer Zirconia/Silane Primer Porcelain Primer Bisco Monobond Plus Ivoclar Vivadent Clearfil Ceramic Kuraray Contain: Silane Contain: Silane & Acidic Phosphate pH 5.0 3.1 3.7 Self-Condensation of Hydrolyzed Silane Silane Methacrylate Pre-hydrolyzed Silane De-activation of Silane To maintain a good shelf-life, pH of one-bottle silane primer systems should be adjusted to 4-5.

Z-PRIME Plus Indications For Use BISCO’s Z-PRIME™ PLUS is intended for use as a surface treatment for the following indirect restoration substrates: Zirconia (e.g. Lava, Cerec, Implant & others) Alumina (e.g. Procera) Metal/alloy (Titanium, PFM, Non-Precious, High Noble) Composite (Direct & Indirect) Endodontic Posts (Zirconia, Metal, Fiber) Intra-oral repairs

Primer Effect on Bond Strength of Resin Cements to Zirconia Using the new primer had a significant effect on increasing the bond strength to zirconia of the tested cements between 86% and 160%  increase. G. MILLAN, M. RAAD, M. ATTAR, and D. NATHANSON, Primer Effect on Bond Strength of Resin Cements to Zirconia, J Dent Res 89(Spec Issue A): Abstr. 1018, 2010

Strong Bond Strengths to Different Substrates With Z-PRIME™ Plus with no primer Cement-Self Cured Zirconia 23 MPa 4 MPa Alumina 18 MPa 3 MPa Titanium 22 MPa Non-precious 23 MPa Stainless Steel 24 MPa Gold 20 MPa Composite 27 MPa

Unique Benefits Unparalleled bond strengths to Zirconia, Alumina and Metal Restorations

High S/C & L/C Bonds SBS of Z-PRIME™ Plus on Different Dental Substrates w/ Duolink™ 5 10 15 20 25 30 35 Fiber Post Composite Gold Rex III Option Stainless Steel Titanium Ceramic Alumina Zirconia SBS(MPa) No Primer ZPRIME+ -S/C ZPRIME+ -L/C

not requiring refrigeration… Bisco’s new DuoLink™ SE Kit including Z-PRIME Plus and Bis-Silane™ offers a system that provides “Confidence in Indirect Adhesion. The stability of the chemistry is demonstrated by not requiring refrigeration… New

**: Silane is not stable in the present of acidic phosphate monomer. Competitors Product Applications Components Shelf-life Z-PRIME™ Plus Bisco Released 2009 Zirconia, Alumina, Metal Zirconia, Alumina Zirconia, Alumina, Metal, Silica-ceramics 2y/room temp. 2y/r.t.*(Duolink™) 2y/rom temp. 2y/refrig.*(ResiCem) 2y/refrig.*(Multilink) 2y/refrig.*(Multilink 2y/refrig 2y/refrig.*(Panavia) BPDM, Phosphate, Ethanol Phosphonate, Acetone t-butyl alcohol Phosphate, Silane** AZ Primer Shofu Released 2009 Metal/Zr Primer Ivoclar Vivadent Monobond Plus Ivoclar Vivadent Released 2009 Clearfil Ceramic Kuraray **: Silane is not stable in the present of acidic phosphate monomer. *: Shelf-life of its corresponding cement.

Unique Benefits Compatible with light-cured and dual-cured resin luting cements

Stronger Bonding: SBS to Zirconia Cement-Light Cured Z-PRIME™ Plus Duolink™ Bisco 29 MPa Clearfil Ceramic Panavia F2.0 Kuraray 8 MPa AZ Primer ResiCem Shofu 21 MPa Metal/Zr Primer Multilink Automix Ivoclar Vivadent 16 MPa Monobond Plus Multilink Automix Ivoclar Vivadent 26 MPa

Stronger Bonding: SBS to Zirconia Cement-Self Cured Z-PRIME™ Plus Duolink™ Bisco 23 MPa Clearfil Ceramic Panavia F2.0 Kuraray 9 MPa AZ Primer ResiCem Shofu 13 MPa Metal/Zr Primer Multilink Automix Ivoclar Vivadent 8 MPa Monobond Plus Multilink Automix Ivaclar Vivadent 11 MPa

Durable Bonding: SBS to Zirconia After Aging Aged 3 days in boiling water, equiv. to 6 years at 37 °C. Cement-Light Cured. Z-PRIME™ Plus Duolink™ Bisco 29 MPa (Day 1) 28 MPa (6 years) Clearfil Ceramic Panavia F2.0 Kuraray 8 MPa (Day 1) 3 MPa (6 years) AZ Primer ResiCem Shofu 21 MPa (Day 1) 18 MPa (6 years) Monobond Plus Multilink Automix Ivoclar Vivadent 26 MPa (Day 1) 16 MPa (6 years)

Durable Bonding: SBS to Zirconia After Aging Aged 3 days in boiling water, equiv. to 6 years at 37 °C. Cement-Self Cured. Z-PRIME™ Plus Duolink™ Bisco 23 MPa (Day 1) 16 MPa (6 years) Clearfil Ceramic Panavia F2.0 Kuraray 9 MPa (Day 1) 2 MPa (6 years) AZ Primer ResiCem Shofu 13 MPa (Day 1) 6 MPa (6 years) Monobond Plus Multilink Automix Ivoclar Vivadent 11 MPa (Day 1) 7 MPa (6 years)

Comparison of Zirconia Restoration Luting Options: SBS to Zirconia Cement-Self Cured Resin Modified Glass Ionomer Cements RelyX Luting+ (3M ESPE) FujiCEM (GC) SmartCem2 (Dentsply) BisCem (Bisco) UniCem (3M ESPE) Z-Prime™ Plus w/ Duolink™ (Bisco) Duolink (Bisco) 4 MPa 8 MPa Self-Adhesive Resin Cements 11 MPa 12 MPa 6 MPa Primer w/ Resin Cement 23 MPa Traditional Resin Cement without Primer (Control) 4 MPa

Average Shear Bond Strength of Zirconia Primers with their Corresponding Self-cure Resin Cements

Phosphate Monomer (MDP), BPDM, ethanol Contains: Phosphate Monomer (MDP), BPDM, ethanol Strong Bond between Resin-cements/composites and: Zirconia Alumina Metals Titanium, Stainless steel, Rexilium, Option, Gold Composites Instruction for Use: Apply 1-2 coats Dry Proceed with cementation. Zr, Al, or Metal etc Dentin Z-PRIME PLUS Duolink

Technique For Placement Clean the internal surface of the restoration; rinse and air dry. Apply 1-2 coats of Z-PRIME™ Plus, uniformly wetting the internal surface. Dry with an air syringe for 3-5 seconds. Proceed with cementation using a luting cement (e.g. DUO-LINK™).

Cementing Zirconia Crowns Z-Prime D Zr BisCem For Full/Retentive Zr Crowns use Biscem® with Z-PRIME™ Plus

Bonding Zirconia Crowns Z-Prime D Zr Adhesive DuoLink Cement Short/Tapered, Non-retentive Zr Crown adhesively bond with Resin Cement

New zirconia primer improves bond strength of resin-based cements. “Improved marginal adaptation, prevention of microleakage, increased fracture strength, and increased retention in situations where mechanical retention does not exist constitute the benefits of a stable and durable resin bond to zirconia.” Magne P, et al. New zirconia primer improves bond strength of resin-based cements. Dent Mater (2009), doi:10.1016/j.dental.2009.12.005 New zirconia primer improves bond strength of resin-based cements.

New zirconia primer improves bond strength of resin-based cements. “The groups where the experimental zirconia primer (ZrP-groups) was used presented the highest mean bond strength values.” “The groups that did not receive the experimental primer (NP groups) and the group treated with the MDP-containing primer (CCP-group) presented the lowest mean bond strength values” Magne P, et al. New zirconia primer improves bond strength of resin-based cements. Dent Mater (2009), doi:10.1016/j.dental.2009.12.005

“Confidence in Adhesion” Proprietary MDP and carboxylic acid monomers Significantly enhances bond strengths of other resin cements* Compatible with light-cured and dual-cured resin luting cement Convenient, single bottle delivery offers ease of dispensing Fast/Predictable Cementation *Data on file, BISCO, Inc.