Prostaglandin E2 control of T cell cytokine production is functionally related to the reduced lymphocyte proliferation in atopic dermatitis Sai Chan,

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Prostaglandin E2 control of T cell cytokine production is functionally related to the reduced lymphocyte proliferation in atopic dermatitis Sai Chan, MDa, William R. Henderson, MDb, Shi-Hua Li, MDa, Jon M. Hanifin, MDa Journal of Allergy and Clinical Immunology Volume 97, Issue 1, Pages 85-94 (January 1996) DOI: 10.1016/S0091-6749(96)70286-5 Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Phytohemagglutinin-stimulated proliferation indices of normal and AD lymphocytes. Normal (open) and AD (solid) PBMC, in RPMI medium 1640/15% FCS, were incubated with PHA (0.5 to 10 μg/ml) for 24 hours. Tritiated thymidine uptake was added for the last 8 hours. Values represent the mean ± SEM of three experiments (*p < 0.05; **p < 0.01). Journal of Allergy and Clinical Immunology 1996 97, 85-94DOI: (10.1016/S0091-6749(96)70286-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Correlation between proliferative index and T cell cytokine production. Coefficient of correlation (r) was determined by linear regression plots for PI versus IFN-γ (A) and PI versus IL-4 (B) in normal (open) and AD (solid) PBMC cultures. Journal of Allergy and Clinical Immunology 1996 97, 85-94DOI: (10.1016/S0091-6749(96)70286-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Correlation between proliferative index and T cell cytokine production. Coefficient of correlation (r) was determined by linear regression plots for PI versus IFN-γ (A) and PI versus IL-4 (B) in normal (open) and AD (solid) PBMC cultures. Journal of Allergy and Clinical Immunology 1996 97, 85-94DOI: (10.1016/S0091-6749(96)70286-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Effect of IFN-γ on proliferation index. PBMC were incubated with varying concentrations of PHA (0.5 to 10.0 μg/ml) in the presence of IFN-γ (100 U/ml). (Open squares = normal, closed squares = AD; *p < 0.05, comparing AD control to IFN-γ treated AD (n = 3); controls are shown in Fig. 1.) Journal of Allergy and Clinical Immunology 1996 97, 85-94DOI: (10.1016/S0091-6749(96)70286-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 4 Effect of IL-4 on proliferation index. Normal (solid columns) and AD (hatched columns) PBMC were incubated with IL-4 (100 U/ml) simultaneously with PHA (10 μg/ml) or as described in Methods. The data are the mean ± SE of three experiments. PI of IL-4 treated PBMC from normal versus AD donors. (*Difference between IL-4 treated and untreated AD cells; *p < 0.05.) Journal of Allergy and Clinical Immunology 1996 97, 85-94DOI: (10.1016/S0091-6749(96)70286-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 5 Effect of PGE2 on T cell IFN-γ production. Normal (solid columns) and AD (hatched columns) T cells at 2 × 106 cells/ml were stimulated with PMA (500 ng/ml) and calcium ionophore A23187 (100 ng/ml) in the absence or presence of 10 μmol/L PGE2 for 24 hours. The values represent the mean ± SE of seven experiments. IFN-γ levels were determined by means of ELISA as described in Methods. (*p < 0.05, control vs PGE2-treated normal cells; **p = 0.002, control vs PGE2-treated AD cells.) Journal of Allergy and Clinical Immunology 1996 97, 85-94DOI: (10.1016/S0091-6749(96)70286-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 6 Effect of PGE2 on T cell IL-4 production. Normal (solid columns) and AD (hatched columns) T cells at 2 × 106 cells/ml were incubated with PMA (500 ng/ml) and calcium ionophore A23187 (100 ng/ml) ± 10 μmol/L PGE2 for 24 hours. The values represent the mean ± SE of seven experiments. IL-4 levels were determined by means of ELISA as described in Methods. (*p = 0.0478, control vs PGE2-treated AD cells.) Journal of Allergy and Clinical Immunology 1996 97, 85-94DOI: (10.1016/S0091-6749(96)70286-5) Copyright © 1996 Mosby, Inc. Terms and Conditions