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The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics  Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,

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Presentation on theme: "The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics  Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,"— Presentation transcript:

1 The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics  Elcio O. Vianna, MD, PhD, Jay Westcott, PhD, Richard J. Martin, MD  Journal of Allergy and Clinical Immunology  Volume 102, Issue 4, Pages (October 1998) DOI: /S (98)70274-X Copyright © 1998 Mosby, Inc. Terms and Conditions

2 Fig. 1 Effects of dexamethasone on PHA-induced proliferation of peripheral blood T cells from subjects with asthma (asthma group) and normal subjects (control group) during URI (solid line) and recovery (dotted line). Proliferation (mean ± SEM) is expressed as a percentage of the proliferation obtained in the absence of any steroid (positive control). *P < .05 compared with the recovery phase. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98)70274-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

3 Fig. 2 Effects of hydrocortisone on pha-induced proliferation of peripheral blood t cells from subjects with asthma (asthma group) and normal subjects (control group) during uri (solid line) and recovery (dotted line). proliferation (mean ± sem) is expressed as a percentage of the proliferation obtained in the absence of any steroid (positive control). *P < .05 compared with the recovery phase. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98)70274-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

4 Fig. 3 Proliferation of peripheral blood T cells from subjects with asthma (asthma group) and normal subjects (control group) during URI and recovery. Proliferation is expressed as incorporation of [3 H]-thymidine (cpm); P < .05 refers to the comparison between infection and recovery within group. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98)70274-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

5 Fig. 4 Concentrations of TNF-α, IFNγ, and IL-10 in the culture of PHA-stimulated PBMC from subjects with asthma (asthma group) and normal subjects (control group) during URI (cross-hatched bars) and recovery (open bars). Data are expressed as mean ± SEM. *Significant difference (P < .05) between infection and recovery (within group). +Significant difference (P < .05) between asthma group and control group. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98)70274-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

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