1. A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children 
Mark Boguniewicz, MDa, Virginia C. Fiedler, MDb, Sharon Raimer, MDc, Ira D. Lawrence, MDd, Donald Y.M. Leung, MD, PhDa, Jon M. Hanifin, MDe 
Journal of Allergy and Clinical Immunology 
Volume 102, Issue 4, Pages (October 1998)
DOI: /S (98)
Copyright © 1998 Mosby, Inc. Terms and Conditions

2. Fig. 1
Trial profile.
Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) )
Copyright © 1998 Mosby, Inc. Terms and Conditions

3. Fig. 2
Left ear of 12-year-old boy who entered the study with moderate atopic dermatitis at baseline (A) and day 15 (B). Improvement was noted by physician beginning on day 4 of treatment with 0.03% tacrolimus ointment.
Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) )
Copyright © 1998 Mosby, Inc. Terms and Conditions

4. Fig. 3
Modified Eczema Area and Severity Index (mean ± SEM). At end of treatment, each of 3 tacrolimus groups had significantly greater (P < .001) reduction in modified Eczema Area and Severity Index compared with vehicle group.
Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) )
Copyright © 1998 Mosby, Inc. Terms and Conditions

5. Fig. 4
Head and Neck Total Score (mean ± SEM). At end of treatment, each of 3 tacrolimus groups had significantly greater (P < .001) reduction in Total Score of head and neck region compared with vehicle group.
Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) )
Copyright © 1998 Mosby, Inc. Terms and Conditions