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Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use  Daniel A. Searing, MD, Yong Zhang, PhD, James.

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Presentation on theme: "Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use  Daniel A. Searing, MD, Yong Zhang, PhD, James."— Presentation transcript:

1 Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use  Daniel A. Searing, MD, Yong Zhang, PhD, James R. Murphy, PhD, Pia J. Hauk, MD, Elena Goleva, PhD, Donald Y.M. Leung, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 125, Issue 5, Pages (May 2010) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Distribution of VitD levels. VitD levels are expressed as serum 25-hydroxyvitamin D. The median value was 31 ng/mL. Forty-seven percent of asthmatic patients had insufficient levels of VitD (<30 ng/mL). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 VitD (VD)–potentiated DEX-mediated transactivation in human PBMCs enhances DEX induction of MKP1(A) and IL10(B) mRNA. PBMCs from patients with asthma were cultured with 10 nmol/L VitD or media alone for 24 hours and supplemented with 10 or 100 nmol/L DEX for the last 3 hours of culture. MKP1 mRNA levels were detected by means of real-time PCR and were normalized to actin mRNA. Values represent means ± SEMs (n = 11). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 VitD augments DEX's effect on TSST-1–stimulated lymphocyte proliferation in human PBMCs. PBMCs from healthy control subjects were treated with DEX and VitD, as indicated in the Methods section. Tritiated thymidine was added to the medium 18 hours before collecting the cells. Cell division was estimated based on tritiated thymidine incorporation (n = 4). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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