MOTOR NEURON DISEASE The motor neuron diseases (or motor neuron diseases) (MND) are a group of neurological disorders that selectively affect motor neurons the cells that control voluntary muscle activity including speaking, walking, breathing, swallowing and general movement of the body.

SYMPTOMS Muscle wasting Progressive weakness Muscle fasciculation Overactive tendon reflexes Slurred speech Spasticity in the arms and legs Neurological examination presents specific signs associated with upper and lower motor neuron degeneration

Patients suffering with MND diagnosed by Physical and Neurological Examination Overall improvement in Muscle strength Improvement in Sensory symptoms Improvement in problems in Walking Improvement in problems in Bladder/ bowel control Improvement in Speech Improvement in Ataxia Patient Selection Benefits

CEREBRAL PALSY Cerebral palsy is a group of disorders involving movement, learning, hearing, seeing and thinking that occur due to problems with brain development.

SYMPTOMS Abnormal movements, sensations and muscle tone. Decreased intelligence Difficulty sucking or feeding in infants Hearing problems Spasticity in arms or legs Learning disabilities Limited range of motion Partial or full loss of movement (paralysis) Peg teeth Seizures Speech problems (dysarthria) Urinary incontinence Vision problems Vomiting or constipation

Patient Selection Benefits Improvement in Ataxia Improvement in Cognitive function Improvement in Speech, Language and Communication Improvement in walking and muscle power of hands and legs Cerebral palsy diagnosed on the basis of Physical examination of Muscle tone, muscle power. Neurological examination for Speech and Communication

MULTIPLE SCLEROSIS Multiple sclerosis is an autoimmune disease that affects the brain and spinal cord (central nervous system). Multiple sclerosis (abbreviated to MS, known as disseminated sclerosis or encephalomyelitis disseminata) is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms

SYMPTOMS Loss of balance Muscle spasms Numbness or abnormal sensation in any area Problems moving arms or legs Problems walking Constipation and stool leakage Difficulty beginning to urinate Double vision Uncontrollable rapid eye movements Decreased attention span, poor judgment and memory loss Difficulty reasoning and solving problems

Patient Selection Benefits Diagnosis of Multiple sclerosis, based on clinical, laboratory and radiologic data evaluation reports Imaging studies (Magnetic resonance studies) Improvement in Muscle strength Improvement in Sensory symptoms Improvement in problems in Walking Improvement in problems in Bladder/ bowel control Improvement in Speech Improvement in Ataxia

Parkinson's Disease Parkinson's disease is a disabling condition of the brain characterized by slowness of movement, shaking (tremor), stiffness, and in the later stages, loss of balance. Many of these symptoms are due to the loss of certain groups of nerves in the brain, which results in the lack of a chemical called dopamine

SYMPTOMS Automatic movements (such as blinking) slow or stop Constipation Difficulty swallowing Drooling Impaired balance and walking Muscle aches and pains (myalgia) Difficulty starting or continuing movement, such as starting to walk or getting out of a chair Loss of small or fine hand movements (writing may become small and difficult to read and eating becomes harder) Shuffling gait Slowed movements

Patient Selection Benefits Diagnosis of Parkinsons Disease, based on Neurological examination. Improvement in Motor symptoms like shaking, rigidity, slowness of movement and difficulty with walking and gait Improvement in Cognitive and behavioral symptoms- Dementia attention deficit, memory loss Improvement in Sensory, sleep and emotional symptoms