Figure 2 Targeted versus untargeted metabolomics approaches

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Figure 2 Targeted versus untargeted metabolomics approaches Figure 2 | Targeted versus untargeted metabolomics approaches. Two main approaches exist for carrying out metabolic profiling: targeted and untargeted. The scope of these two types of analysis is different and they both have advantages and disadvantages. Targeted metabolomics approaches have a low detection limit and enable the absolute quantification of the sample. However, targeted methods do not enable the discovery of unknown compounds. Untargeted metabolomics approaches provide a global view of a sample. The disadvantages of untargeted methods include the complex informatics required to interpret the results, the semi-quantitative nature of the methods and the need to validate any identified compounds. Menni, C. et al. (2017) Mixing omics: combining genetics and metabolomics to study rheumatic diseases Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.5