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Figure 3 Strategies to achieve therapeutic inhibition of IL-1

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Presentation on theme: "Figure 3 Strategies to achieve therapeutic inhibition of IL-1"— Presentation transcript:

1 Figure 3 Strategies to achieve therapeutic inhibition of IL-1
Figure 3 | Strategies to achieve therapeutic inhibition of IL-1. Structural, pharmacological and disease characteristics of current interleukin IL-1 inhibitors. Rilonacept has one extracellular domain of IL-1 receptor type 1 (IL-1R1) and one of IL-1 receptor accessory protein (IL-1RAcP) bound to the Fc portion of IgG. AOSD, adult onset Still disease; CAPS, cryopyrin-associated periodic syndrome; CPPD, calcium pyrophosphate disease; CP, calcifying periarthritis; CVD, cardiovascular disease; IL-1Ra, IL-1 receptor antagonist; mAb, monoclonal antibody; RA, rheumatoid arthritis; sJIA, systemic juvenile idiopathic arthritis. Schett, G. et al. (2015) Interleukin‑1 function and role in rheumatic disease Nat. Rev. Rheumatol. doi: /nrrheum

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Abrar M. Radwan Saleh 10926766 Dr. Adham Abo-Taha An-Najah National University College of Pharmacy Pharmacy Program: Pharm D.

Abrar M. Radwan Saleh Dr. Adham Abo-Taha An-Najah National University College of Pharmacy Pharmacy Program: Pharm D.
My Treatment Approach to Rheumatoid Arthritis

My Treatment Approach to Rheumatoid Arthritis
Figure 1 Lymphocytes during the disease

Figure 1 Lymphocytes during the disease
Figure 1 Role of innate lymphoid cells (ILCs) in steady state,

Figure 1 Role of innate lymphoid cells (ILCs) in steady state,
of different experimental arthritis models

of different experimental arthritis models
Figure 1 Historical evolution of the clinical classification and

Figure 1 Historical evolution of the clinical classification and
Figure 2 A timeline summarizing the development of diagnostic tools in rheumatology Figure 2 | A timeline summarizing the development of diagnostic tools.

Figure 2 A timeline summarizing the development of diagnostic tools in rheumatology Figure 2 | A timeline summarizing the development of diagnostic tools.
Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.

Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 1 Enthesitis versus synovitis

Figure 1 Enthesitis versus synovitis
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 1 Structure of TNF antagonists

Figure 1 Structure of TNF antagonists
Figure 1 Induction of immune tolerance

Figure 1 Induction of immune tolerance
Figure 3 Methods to detect trough levels of therapeutic antibodies

Figure 3 Methods to detect trough levels of therapeutic antibodies
Figure 2 Assays for detecting antidrug antibodies to TNF inhibitors

Figure 2 Assays for detecting antidrug antibodies to TNF inhibitors
My Treatment Approach to Rheumatoid Arthritis

My Treatment Approach to Rheumatoid Arthritis
Figure 4 Simplified T cell and antigen presenting

Figure 4 Simplified T cell and antigen presenting
Figure 3 Proposed mechanisms underlying the links

Figure 3 Proposed mechanisms underlying the links

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