Impact of triple combination of gemcitabine‐based chemoirradiation with anti‐PD‐L1 in the KPC tumor allograft Impact of triple combination of gemcitabine‐based.

Slides:

Advertisements

Similar presentations

The expressions of H19 and Igf1r are significantly decreased in the eutopic endometrium of women with endometriosis compared to those without endometriosis.

Advertisements

Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.

Loss of Hdac3 impairs Ar signaling in mouse prostate tissues and has no effect on apoptosis Loss of Hdac3 impairs Ar signaling in mouse prostate tissues.

Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice.

Dual anti‐Ang‐2 and anti‐VEGF therapy acts synergistic on vascular normalization and macrophage infiltration in experimental GBM Dual anti‐Ang‐2 and anti‐VEGF.

The HDAC3 inhibitor suppresses SPOP‐mutated prostate cancer cell growth The HDAC3 inhibitor suppresses SPOP‐mutated prostate cancer cell growth A22Rv1.

Neuro‐inflammatory cytokines, brain microglial activation, and working memory deficits are normalized using LV.IDS.ApoEII, but not LV.IDS in MPS II mice.

PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection Proportion.

Treatment with p38γ/p38δ inhibitor shows antifungal effects in vivo

[68Ga]Pentixafor PET imaging of MM xenografts Real‐time PCR analysis of cxcr4 transcript expression levels in HeLa (negative control) and in MM cell lines.

Reverse cholesterol transport is enhanced after systemic miR‐33 silencing.C57BL/6 mice (n = 7) were infused i.v. with 5 mpk scrambled or anti‐miR‐33 oligonucleotides.

TFE3 regulates glucose homeostasis

AAV8‐hAAT‐FGF21 treatment improves liver fibrosis

Differential accumulation of substrates in vivo

Metabolic profile of Tfe3 KO mice fed a HFD

Roles of systemic versus tumour SK1 in the regulation of local tumour growth and lung colonization/metastasis.A.Effects of siRNA‐mediated SK1 knockdown.

Metabolic profile of Tfe3 KO mice

Impaired fear extinction precedes memory decline in Fmn2 mutant mice

Fig. 8. mRIPO elicits neutrophil influx followed by DC and T cell infiltration into tumors. mRIPO elicits neutrophil influx followed by DC and T cell infiltration.

No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO Cre+ mice No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO.

ADAM8 promotes cancer cell adhesion to endothelial cells via β1‐integrin activation ABlood was drawn using the submandibular collection method from 4 mice/group.

Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),

TFE3 prevents diet‐induced obesity and metabolic syndrome

Fig. 4. Antitumor efficacy of ERY974 against various cancer types.

Expression of PD‐1 on PBMC and malignant exudate T cells

SOM230 increases in vivo sensitivity to gemcitabine of tumour xenograft (MIA PaCa‐2‐Luc cells and CAFs or human PDAC resection) A–CMIA PaCa‐2‐GLuc cells.

Combination of OTX‐015 and PD does not induce overt toxicity

SPRY2 deficiency‐induced SRB1 mediates CRPC

PERK activator treatment protects neurite network

Fig. 4. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in vivo. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in.

Neuro‐inflammatory cytokines, brain microglial activation, and working memory deficits are normalized using LV.IDS.ApoEII, but not LV.IDS in MPS II mice.

WT‐HSCT, LV. IDS, and LV. IDS

BETi potentiate the efficacy of MEKi in NRAS‐mutant melanoma

Nec‐1 inhibits the phosphorylation and aggregation of tau

High frequency and unique tumor‐initiating cells (TICs) in Pten/p53‐deficient mice Flow cytometry profiles of indicated tumors with the CD24 and CD49f.

IR induces cellular damage and a loss of nerves and SOX2 and SOX2+ progenitors can replenish mouse acinar cells in response to cholinergic mimetics IR.

Treatment with AAV8‐hAAT‐FGF21 improves insulin sensitivity and glucose tolerance Treatment with AAV8‐hAAT‐FGF21 improves insulin sensitivity and glucose.

Effects of in vivo Nutlin‐3 treatment on CSC content of Numb− and Numb+ tumors Effects of in vivo Nutlin‐3 treatment on CSC content of Numb− and Numb+

Akt inhibition with AZD5363 does not enhance the radiosensitivity of tumour cells in vitro Akt inhibition with AZD5363 does not enhance the radiosensitivity.

Normal priming and expansion of functional T cells in the spleen during concurrent co‐infection Normal priming and expansion of functional T cells in the.

IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice ARepresentative.

LV.IDS and LV.IDS.ApoEII improve brain‐specific IDS activity and express supra‐physiological levels of active IDS in peripheral organs LV.IDS and LV.IDS.ApoEII.

Safety profile of reversibly immortalised human mesoangioblasts

Impact of ONX 0914 on abundance and dissemination of monocytes/macrophages during CVB3 infection Impact of ONX 0914 on abundance and dissemination of monocytes/macrophages.

EnAd‐EpCAMBiTE shows reproducible activity within an expanded cohort of patient malignant peritoneal and pleural exudates EnAd‐EpCAMBiTE shows reproducible.

Enhancement of receptor endocytosis, as well as cellular apoptosis, may explain the cooperative anti‐tumor actions of 3×mAbs and osimertinib Enhancement.

The antitumor activity of olaparib in PDXs identifies a subset of PARPi‐sensitive tumors The antitumor activity of olaparib in PDXs identifies a subset.

MiR‐34a‐5p functionally contributes to arrested lung alveolarization in response to hyperoxia miR‐34a‐5p functionally contributes to arrested lung alveolarization.

Therapeutic role of TR in HFD‐established diabetic mice

ADAM8 knockdown profoundly decreases orthotopic tumor formation, CTC spread and metastasis A–DStable ADAM8 KD (shA8) clones were characterized in vitro.

The CHCH domain is necessary for mitochondrial import of CHCHD10

miR‐205 modulates tumor cell sensitivity to MET‐TKIs

P2X4R blockade increases autoimmune inflammation

Re‐expression of the AXIN1 coding sequence re‐sensitizes VACO6R cells to PORCN inhibition Re‐expression of the AXIN1 coding sequence re‐sensitizes VACO6R.

Etifoxine modulation of T‐cell activity during EAE

Therapeutic activity of gal‐encapsulated cytotoxic drugs on tumor xenografts Therapeutic activity of gal‐encapsulated cytotoxic drugs on tumor xenografts.

Tissue‐specific differences in the levels of CoQ9, CoQ10, and DMQ9, and in the DMQ9/CoQ9 ratio after β‐RA treatment in Coq9R239X mice Tissue‐specific differences.

Sox2 is essential for SLG regeneration following radiation injury

Antagonizing miR‐34a function partially restores proper lung alveolarization Antagonizing miR‐34a function partially restores proper lung alveolarization.

GM1 decreases neuropathology and weight loss in R6/2 mice

AOX modifies RISP assembly and rescues mitochondrial respiration in tissue‐specific fashion AOX modifies RISP assembly and rescues mitochondrial respiration.

Symptomatic rescue of double‐transgenic mice without decreased protein aggregation The expression of exogenous HMGB1‐FLAG (detected with an anti‐FLAG antibody)

Single‐molecule dynamics of the active mutant, hDIA1(R1204X), in XTC cells Single‐molecule dynamics of the active mutant, hDIA1(R1204X), in XTC cells A–DGFP‐tagged.

The oligoclonal antibody overcomes the C797S mutation‐mediated resistance to osimertinib The oligoclonal antibody overcomes the C797S mutation‐mediated.

CAR T‐cell generation in human PBMC‐transplanted mice

Absence of miR‐21 in macrophages promotes foam cell formation

SEMA3C regulates prostate cancer cell growth

The GBS hemolytic pigment/lipid toxin induces caspase 1 activation and pyroptosis THP‐1 macrophages were treated with GBS pigment, and caspase 1 activation.

Effects of tumour size on response to treatment in the KPC model.

Ki-67 expression in M31- and H3-treated tumors (A) and respective Ki-67 labeling indices in the two groups of tumors (B). Ki-67 expression in M31- and.

Presentation transcript:

Impact of triple combination of gemcitabine‐based chemoirradiation with anti‐PD‐L1 in the KPC tumor allograft Impact of triple combination of gemcitabine‐based chemoirradiation with anti‐PD‐L1 in the KPC tumor allograft AMice were treated with either gemcitabine (days 0, 3), anti‐PD‐L1 (days 4, 7, 10, and 13), 12 Gy (day 4) alone, or in combinations, as indicated (n = 8 mice per group). The average time (days) for tumors to reach a volume of 400 mm3 from day 0 is shown (means ± SD, n = 1, one‐way ANOVA, Bonferroni test). No weight loss was observed in the in vivo experiment.B, CRT plus anti‐PD‐L1 reverses T‐cell exhaustion (B) and increases CD8:Treg ratio (C). Bar graphs show quantitation of T‐cell activation markers and CD8:Treg ratio in tumor samples based on flow cytometry analysis, as indicated (n = 5 per group; means ± SD, n = 1, one‐way ANOVA, Bonferroni test). Abul Azad et al. EMBO Mol Med. 2016;emmm.201606674 © as stated in the article, figure or figure legend