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Impaired fear extinction precedes memory decline in Fmn2 mutant mice

Published byΦιλομήλα Πυλαρινός Modified over 5 years ago

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Presentation on theme: "Impaired fear extinction precedes memory decline in Fmn2 mutant mice"— Presentation transcript:

1 Impaired fear extinction precedes memory decline in Fmn2 mutant mice
Impaired fear extinction precedes memory decline in Fmn2 mutant mice Freezing behavior tested 24 h after training was similar in 3‐month‐old APPPS1‐21, 5xFAD, and Fmn2−/− mice when compared to corresponding control groups (n = 10/group).Fear extinction in 3‐month‐old APPPS1 mice is similar to a non‐transgenic control group (n = 9/group).Fear extinction in 3‐month‐old 5xFAD mice is similar to a non‐transgenic control group (n = 9/group).Extinction learning in the contextual fear conditioning paradigm is impaired in Fmn2−/− mice (n = 9/group; ***P < 0.001, F = 21.77, two‐way RM ANOVA).Freezing behavior was tested 24 h after training in 8‐month‐old APPPS1‐21, 5xFAD, and Fmn2−/− mice. A significant impairment in associative memory was observed when comparing APPPS1 mice (n = 10) to a corresponding control group (n = 8; **P < 0.01, t‐test), when comparing 5xFAD mice (n = 10) to a corresponding control group (n = 8; **P = 0.01, t‐test), and when comparing Fmn2−/− mice (n = 10) to corresponding Fmn2+/+ wild‐type mice (n = 10; ***P < 0.0001, t‐test).Freezing was analyzed in 3‐ (n = 11), 12‐ (n = 9), and 16 (n = 8)‐month‐old male wild‐type mice. A significant impairment (***P < 0.0001, t‐test) was observed in 16‐month‐old animals when compared to either 3‐ or 12‐month‐old animals.Fmn2 expression measured in blood samples via qPCR was reduced in PTSD patients (n = 9) when compared to age‐matched controls (n = 7; *P = 0.0361, t‐test).Fmn2 mRNA expression is decreased after dexamethasone treatments in human hippocampal progenitor cells (HPCs) during neuronal proliferation (3 days) and differentiation (10 days) (***Padj < 3.27 × 10−6, one‐way ANOVA followed by Bonferroni correction).qPCR revealed that Fmn2 expression is decreased (*P = 0.037, t‐test) in AD patients (n = 9) when compared to age‐matched controls (n = 8).Data information: Error bars indicated SEM. Roberto Carlos Agís‐Balboa et al. EMBO J. 2017;36: © as stated in the article, figure or figure legend

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