1. Reverse cholesterol transport is enhanced after systemic miR‐33 silencing.C57BL/6 mice (n = 7) were infused i.v. with 5 mpk scrambled or anti‐miR‐33 oligonucleotides for 2 consecutive days, and 5 days later received 1 × 106 radiolabelled macrophages by i.p. injection.
Reverse cholesterol transport is enhanced after systemic miR‐33 silencing.C57BL/6 mice (n = 7) were infused i.v. with 5 mpk scrambled or anti‐miR‐33 oligonucleotides for 2 consecutive days, and 5 days later received 1 × 106 radiolabelled macrophages by i.p. injection. Mice were kept on chow for 48 h until sacrifice.A.Different parameters in mice receiving scrambled (open bars) and anti‐miR‐33 (closed bars) treatment at the time of sacrifice. Notice the increase in bile recovery from the gallbladder.B.Percentage of total injected dpm recovered in the plasma at different time points after injection of radiolabelled cells.C‐E.Percentage of total injected dpm recovered at the time of sacrifice in liver, bile from the gallbladder and faeces of the same mice. Data shown as mean ± SD; *p < 0.05; **p < 0.01.
Ryan M. Allen et al. EMBO Mol Med. 2012;4:
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