From: Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia–Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats.

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From: Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia–Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats Anesthes. 2016;124(6):1296-1310. doi:10.1097/ALN.0000000000001113 Figure Legend: The hibernator cardioprotective phenotype is associated with preservation of peroxisome proliferator–activated receptor-α (PPAR-α) activity by transcription factor–binding assay in hibernating arctic ground squirrel (HIB-AGS) compared to rat, at both reperfusion time points (A). A diagram of lipid metabolism focused on lipid transport into the mitochondrion is given in B. Increased expression of multiple fatty acid transporters and enzymes of fatty acid metabolism may contribute to increased metabolic efficiency in HIB-AGS hearts. PPAR-α-regulated transactivation effects maintain lipid metabolism under conditions of physiologic stress. AGS = arctic ground squirrel. Date of download: 11/10/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.

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