1. From: Physiologic and Antinociceptive Effects of Intrathecal Resiniferatoxin in a Canine Bone Cancer Model
Anesthes. 2005;103(5):
Figure Legend:
Fig. 1. Average mean arterial blood pressure and heart rate of 5 normal dogs and 20 dogs with bone cancer, during general anesthesia, after intrathecal administration of resiniferatoxin. Normal dogs were monitored for 240 min, and dogs with bone cancer were monitored for 30 min. Normal dogs received 0.1 μg/kg (n = 2), 1.2 μg/kg (n = 2), and 3.0 μg/kg (n = 1) resiniferatoxin. All dogs with bone cancer received 1.2 μg/kg of resiniferatoxin. Time 0 represents the minute before intrathecal injection. 
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