KTN Ltd and the Health Community Prof Mehdi Tavakoli, KTN Ltd Achieving Patient Access to Highly Novel Medical and Regenerative Technologies Wednesday 9 April 2014 York

KTN Ltd and the Health Community On April 1 st 2014 the current Knowledge Transfer Networks merged to become a single company to better represent the interdisciplinary nature of innovation evolution not revolution Chris Warkup is the CEO of The KTN Sue Dunkerton part of senior leadership team Most Health KTN staff joined the new entity

KTN: Building a Healthy Nation through Business Innovation KTN Ltd supports business innovations through partnerships, access to funding and knowledge transfer. Bringing together & facilitating collaborations with a common goal Connecting Partners Identify and influence new and existing sources of funding Access to Funding Opening doors to wider networks of people/organisations Knowledge Transfer

Clinical Needs Stratified Medicine Detection and Identification of Infectious Agents Regenerative Medicine Assisted/ Independent Living UK Health Priority Areas Novel Therapies Emerging Medical Technologies Synthetic Biology High Value Manufacturing Data and Digital Healthcare Biopharmaceutical & Bioprocessing

Support community engagement activities across the breadth of the RegenMed sector – Make links across priority areas and KTN communities : from bioprocessing to transport to sensors to creative – Industrially led Interest Groups Meetings eg: Cardiovascular Bioprocessing for Advanced Therapies Unmet Clinical Needs – Clinical interactions – Engagement with relevant RC funded centres: EPSRC, MRC – Engage with UKRMP – Support the ATMP manufacturing Community – Work with CT Catapult – Support Trade associations work eg BIA CTRMAC Input to Gov’t led initiatives – BIS, DH, RMEG Identify KT gaps and address by catalysing community building Support development of partnerships involved in TSB funding Health Community in Regen Med

KTN (Health) TSB InternationalRegionalNational HTCs NIHR AHSN Network Centres for Inn. Manufacture Research Councils MHRA DH RMEG European Commission FDA FCO-SIN UKTI Healthcare UK BIS Charities One Nucleus MediWales AHSNs NHS Trusts/ Clinicians BioNow Companies Universities Doctoral Training Centres ABHI/BIVD A BIA/ABPI Supporting Organisations NOCRI DECs European BioTech Network BRCs/BRUs IKC Regener8 MedilinksMedilink UK NICE NISCHR

BioMedical Catalyst R&D Grant: Scotland KTA Case Awards KTP i4i Finance for Innovation Framework 7 Cooperation Health/NMP/ICT EUROPE TSB NATIONAL Regional Growth Funds Devolved Administrations/ Regional Funding DoH/NIHR Innovation Platforms Basic Research Applied Research Commercialisation TECHNOLOGY READINESS LEVEL (TRL) Manufacturing Advisory Service (MAS) Business Angels Venture Capitalists Private Investors Responsive Mode Research Industrial CASE AWARDS Managed Programmes IKCs RESEARCH COUNCILS Collaborative R & D Catapults HICF TSBSmart SBRI PPP’s Smart: Scotland HTCs H2020 Excellence in Science Leadership in KEITs Societal Challenges

What Happens next– how will we make an impact? KTN, Medical Technologies IKC and Regener8 worked together to bring this meeting and community together The output of today with recommendations will be summarised in a report that will be presented to the Regenerative Medicine Expert Group in support of its work in this area RMEG will be hopefully view the delegate list from today as a GO-TO community for further input, recommendation and learning to support this workstream KTN and partners will work to continue connecting and catalyse innovation

_connect portal THANK YOU THANK YOU

Priority Areas-Clinical Needs Identifying unmet clinical needs and influencing future funding calls (eg TSB Reg Med 2014). Facilitating industry/clinicians collaborations through events. Identifying funding opportunities and collaborating partners. Access to leading clinicians and clinical centres of excellence. Close collaboration with DH, NHS, NIHR, NICE, NOCRI, NHS- 24, NISCHR, HSCNI and influencing future national healthcare innovation strategy. Close collaborations with clinicians-led major initiatives e.g. HTCs, DEC’s, AHSNs, BRCs, etc. Facilitating commercialisation of new products, accelerating regulatory approvals and adoption by the NHS.

Clinicians/Industry Collaborations

Links to Clinicians-Health Technology Cooperatives( HTC) NHS OrganisationClinical Area or Theme Cambridge University Hospitals NHS Foundation Trust Brain Injury - Several theme areas around brain injury of acquired and developmental origin across the acute care pathway: acute care including bedside monitoring, imaging, stem cells, genomic profiling and biomarkers. Sheffield Teaching hospitals NHS Foundation Trust Devices for Dignity - Urinary incontinence and management, renal technologies, assistive and rehabilitative technologies. University Hospitals of Birmingham NHS Foundation Trust Trauma Management - Four clinical themes, which mirror the patient journey: Immediate Care, Secondary Care, Regeneration, Rehabilitation. Leeds Teaching Hospitals NHS Trust Colorectal Therapies - Minimally invasive therapies for colorectal disease with three themes: Engineering, nanotechnology, biosensing. Barts Health NHS Trust Chronic gastrointestinal (GI) disease - Including prevention of stoma complications, neuromodulation for faecal incontinence, novel diagnostics to stratify chronic GI disease, improved safety and effectiveness of GI surgery. Guy’s and St Thomas’ NHS Foundation Trust Cardiovascular disease - Four themes: Artherosclerosis, Cardiac arrhythmias, Heart failure and structural heart disease. Bradford Teaching Hospitals NHS Foundation Trust Wound Prevention and Treatment - Wound management - patient led centralised wound research strategy. Nottinghamshire Healthcare NHS Trust, Institute of Mental Health Mental Health and neurodevelopmental disorders - Attention Deficit Hyperactivity Disorder, Tourette’s Syndrome and autism, depression and bipolar disorder.

Healthcare Technology Co-operatives (HTCs) Chronic gastrointestinal disease (enteric) HTC Barts Health NHS Trust Chronic gastrointestinal disease (enteric) HTC Barts Health NHS Trust Trauma Management HTC University Hospitals of Birmingham NHS Foundation Trust Trauma Management HTC University Hospitals of Birmingham NHS Foundation Trust Colorectal Therapies HTC Leeds Teaching Hospitals NHS Trust. Colorectal Therapies HTC Leeds Teaching Hospitals NHS Trust. Cardiovascular disease HTC Guy’s and St Thomas’ NHS Foundation Trust Cardiovascular disease HTC Guy’s and St Thomas’ NHS Foundation Trust Wound prevention and treatment HTC Bradford Teaching Hospitals NHS Foundation Trust. Wound prevention and treatment HTC Bradford Teaching Hospitals NHS Foundation Trust. Brain Injury HTC Cambridge University Hospitals NHS Foundation Trust Brain Injury HTC Cambridge University Hospitals NHS Foundation Trust Mental health and neurodevelopmental disorders HTC Nottinghamshire Healthcare NHS Trust, Institute of Mental Health Mental health and neurodevelopmental disorders HTC Nottinghamshire Healthcare NHS Trust, Institute of Mental Health Devices for Dignity HTC Sheffield Teaching Hospitals NHS Foundation Trust Devices for Dignity HTC Sheffield Teaching Hospitals NHS Foundation Trust

Links to Clinicians-NIHR-Diagnostic Evidence Co-operatives