1. Discussion points from the Science|Business Executive Forum UCL, 5 November 2008 1. Technology 2. Money 3. People 4. Global Trends

2. 1. TECHNOLOGY and PROCESSES Convergence - of once-disparate technologies in biopharmaceuticals, medical devices, diagnostic equipment, bioinformatics, medical imaging and other fields. Genomics - By 2020 every patient will have their genome sequenced, driving improvements in diagnosis and treatments, paving the way to personalised medicine Prevention and early detection - of disease with biomarkers and other diagnostic devices. Patients will do more for themselves through self-monitoring. In parallel, there will be a move to less invasive treatments A new view of clinical studies – in research-intensive hospitals data and outcomes for every patient coming through the door will be captured and analysed.

3. 2. MONEY Finance - is needed across the piece, from funding for basic research, to seed funding for start-ups, venture finance for commercialisation. Affordability and Reimbursement – how will these products and improved services be funded? A New View of Value – advanced treatments may be expensive – but they will lead to cost savings elsewhere. Health Technology Assessments need to broaden out in the face of this new paradigm Venture Capitalists - and other investors – must embrace and help to drive the vision

4. 3. PEOPLE Technology Transfer - the vision to be delivered there must be real links between universities and industry and patients. Personalised Medicine - Put patients at the centre and let them decide if they want to take risk of being in a trial, or have a treatment Data Protection, Privacy and Management - Biobanks and data repositories are at heart of this movement – we need to look at ownership of data, how it is transmitted, how large datasets are managed Partnership - The public needs to be consulted and in particular younger people need to be asked for their views Evolution of the Healthcare Profession – with support from expert systems and monitoring healthcare will become more formulaic. Making clinical judgements will be open to people with less expert training

5. 4. GLOBAL TRENDS Ageing populations – increasing the burden of chronic diseases Growing health inequality – not only in developing countries, but also from one developed country to another Regulators – there is a need for harmonisation of regulatory authorities worldwide.