1. Genetically Modified Foods

2. What Is Biotechnology? Using scientific methods with organisms to produce new products or new forms of organisms Using scientific methods with organisms to produce new products or new forms of organisms Any technique that uses living organisms or substances from those organisms to make or modify a product, to improve plants or animals, or to develop microorganisms for specific uses Any technique that uses living organisms or substances from those organisms to make or modify a product, to improve plants or animals, or to develop microorganisms for specific uses

3. What Is Biotechnology? GMO- genetically modified organisms. GMO- genetically modified organisms. GEO- genetically enhanced organisms. GEO- genetically enhanced organisms. With both, the natural genetic material of the organism has been altered. With both, the natural genetic material of the organism has been altered. Roots in bread making, wine brewing, cheese and yogurt fermentation, and classical plant and animal breeding Roots in bread making, wine brewing, cheese and yogurt fermentation, and classical plant and animal breeding

4. What Is Biotechnology? Manipulation of genes is called genetic engineering or recombinant DNA technology Manipulation of genes is called genetic engineering or recombinant DNA technology Genetic engineering involves taking one or more genes from a location in one organism and either Genetic engineering involves taking one or more genes from a location in one organism and either Transferring them to another organism Transferring them to another organism Putting them back into the original organism in different combinations Putting them back into the original organism in different combinations

5. What Are the Areas of Biotechnology? Organismic biotechnology- uses intact organisms; Does not alter genetic material Organismic biotechnology- uses intact organisms; Does not alter genetic material Molecular biotechnology- alters genetic makeup to achieve specific goals Molecular biotechnology- alters genetic makeup to achieve specific goals Transgenic organism- an organism with artificially altered genetic material Transgenic organism- an organism with artificially altered genetic material

6. What Are the Benefits of Biotechnology? Medicine Medicine Human Human Veterinary Veterinary Biopharming Biopharming Environment Environment Agriculture Agriculture Food products Food products Industry and manufacturing Industry and manufacturing

7. What Did These Individuals Contribute to Biotechnology? Anton van Leeuwenhoek Anton van Leeuwenhoek Discovered cells Discovered cells Bacteria Bacteria Protists Protists Red blood Red blood

8. What Did These Individuals Contribute to Biotechnology? Gregor Johan Mendel Gregor Johan Mendel Discovered genetics Discovered genetics

9. What Did These Individuals Contribute to Biotechnology? Walter Sutton Walter Sutton Discovered Chromosomes Discovered Chromosomes

10. What Did These Individuals Contribute to Biotechnology? Thomas Hunt Morgan Thomas Hunt Morgan Discovered how genes are transmitted through chromosomes and sex linkage Discovered how genes are transmitted through chromosomes and sex linkage

11. What Did These Individuals Contribute to Biotechnology? Ernst Ruska Ernst Ruska Invented the electron microscope Invented the electron microscope

12. What Did These Individuals Contribute to Biotechnology? Sir Alexander Fleming Sir Alexander Fleming Discovered penicillin Discovered penicillin

13. What Did These Individuals Contribute to Biotechnology? Rosalind Elsie Franklin Rosalind Elsie Franklin Research led to the discovery of the double helix structure of DNA Research led to the discovery of the double helix structure of DNA

14. What Did These Individuals Contribute to Biotechnology? James Watson and Francis Crick James Watson and Francis Crick Discovered DNA Discovered DNA

15. What Did These Individuals Contribute to Biotechnology? Mary-Claire King Mary-Claire King Mapped human genes for research of cancer treatments Mapped human genes for research of cancer treatments

16. What Did These Individuals Contribute to Biotechnology? Ian Wilmut Ian Wilmut Created the first true clone, the Dorset ewe Dolly Created the first true clone, the Dorset ewe Dolly

17. What are GM’s? are a result of technology that has altered the DNA of living organisms (animals, plants or bacteria) are a result of technology that has altered the DNA of living organisms (animals, plants or bacteria) Other terms that mean the same thing: Genetically engineered Genetically engineered Transgenic Transgenic Recombinant DNA (rDNA) technology Recombinant DNA (rDNA) technology

18. How does this differ from Mendel and his peas? GM vs. Selective breading Selective breading -slow-imprecise -modification of genes that naturally occur in the organism GM -very fast -precise -can introduce genes into an organism that would not occur naturally!

19. Why do it? Rice- not high in essential nutrients Rice- not high in essential nutrientsModification: + daffodil genes and a bacterium = beta- carotene content drastically increased + daffodil genes and a bacterium = beta- carotene content drastically increased + genes from a french bean = double the iron content. + genes from a french bean = double the iron content. Tomatoes- Introduce genes to increase shelf life. Tomatoes- Introduce genes to increase shelf life.

20. How is this done?: Transgenic tomatoes

21. Other applications Potato - modified to produce a beetle killing toxin Potato - modified to produce a beetle killing toxin Yellow squash – modified to contain to viral genes that resistant the most common viral diseases Yellow squash – modified to contain to viral genes that resistant the most common viral diseases Develop foods that contain vaccines and antibodies that offer valuable protection against diseases such as cholera, hepatitis, and malaria Develop foods that contain vaccines and antibodies that offer valuable protection against diseases such as cholera, hepatitis, and malaria Canola – modified to resist one type of herbicide or pesticide Canola – modified to resist one type of herbicide or pesticide

22. A Local Example: : GM Canola Canadian-Australian Relations Bayer CropScience produces genetically modified canola in Australia for Bayer CropScience produces genetically modified canola in Australia for the Canadian market. It is produced to resist the herbicide “Liberty” and can yield up to 20% higher than conventional canola. the Canadian market. It is produced to resist the herbicide “Liberty” and can yield up to 20% higher than conventional canola.

23. Benefits of Genetic Engineering and Modifying 1. Higher yielding crops, more efficient use of land 2. Can save money and promote higher profits 3. Longer shelf life, less waste Example// Tomatoes from genetically Example// Tomatoes from genetically modified seeds stay fresh modified seeds stay fresh longer. longer. 4. Enhanced taste and quality 5. Reduced maturation time

24. Benefits of Genetic Engineering and Modifying 6. Increased and improved nutrients and stress tolerance - A single gene genetically engineered into cauliflower can increase - A single gene genetically engineered into cauliflower can increase production of beta-carotene 100 times. production of beta-carotene 100 times. - A gene can be implanted into a soybean upgrading the soy protein - A gene can be implanted into a soybean upgrading the soy protein to a quality equal to that of milk. to a quality equal to that of milk. - Corn can be modified to contain its two limiting amino acids, - Corn can be modified to contain its two limiting amino acids, lysine or tryptophan lysine or tryptophan 7. Improved resistance to disease or illness - Foods can be enhanced with phytochemicals that help maintain - Foods can be enhanced with phytochemicals that help maintain health and reduce the risks of chronic disease. health and reduce the risks of chronic disease. 8. Improved crop resistance to disease, pests, weeds and herbicides 9. New products and growing techniques - “Individuals allergic to milk may be able to buy milk that has been - “Individuals allergic to milk may be able to buy milk that has been treated with the lactase enzyme” (Whiney, 2002). treated with the lactase enzyme” (Whiney, 2002). - Creating decaffeinated coffee beans are in a process of research. - Creating decaffeinated coffee beans are in a process of research.

25. Benefits of Genetic Engineering and Modifying Society Society Increased food security for growing populations and growth challenges Increased food security for growing populations and growth challenges (Human Genome Project Information (2003), http://www.ornl.gov/sci/techresources/Hu man_Genome/elsi/gmfood.shtml)

26. Who Uses this technology

27. Risks associated with Genetic Modification 1. Safety Potential human health implications. Potential human health implications. Potential environmental impact. Potential environmental impact. Out-crossing Out-crossing Inevitable out-crossing of transgenic plants with naturally occurring ones. Inevitable out-crossing of transgenic plants with naturally occurring ones. Creation of super-weeds Creation of super-weeds Creation of biological weapons. Creation of biological weapons. 2. Access and Intellectual Property Domination of world food production by a few companies and developing countries. Domination of world food production by a few companies and developing countries.

28. Risks associated with Genetic Modification – cont. 3. Ethics “Playing God” “Playing God” Tampering with nature by mixing genes among species. Tampering with nature by mixing genes among species. 4. Labeling Not mandatory in some countries (e.g., Canada and the United States). Not mandatory in some countries (e.g., Canada and the United States). Mixing GM crops with non-GM confounds labeling attempts. Mixing GM crops with non-GM confounds labeling attempts. 5. Society New advances may be skewed to the interests of rich countries. New advances may be skewed to the interests of rich countries. (Human Genome Project Information (2003), http://www.ornl.gov/sci/techresources/Human_Genome/elsi/gmfood.shtml)

29. Risks with GM continued: Biodiversity Addition of Bt gene into plants including corn, potatoes and cotton to increase resistance to plants Addition of Bt gene into plants including corn, potatoes and cotton to increase resistance to plants Bt gene obtained from Bacillus thuringiensis (a soil bacterium that produces a natural insecticide) Bt gene obtained from Bacillus thuringiensis (a soil bacterium that produces a natural insecticide) Problem: plants producing Bt toxin are releasing toxin in pollen Problem: plants producing Bt toxin are releasing toxin in pollen Draper, D. (2002). Our Environment: A Canadian Perspective 2nd Ed. Scarborough: Thompson Canada Lmt.

30. Pollen from a Bt plant was dusted on to milkweed: Pollen from a Bt plant was dusted on to milkweed: - only 56% of young monarch butterfly larvae lived - only 56% of young monarch butterfly larvae lived - whereas pollen from organic plants dusted on the milkweed produced a survival rate of 100%. Approximately half of the monarch butterfly population live in the “corn belt” of the USA Approximately half of the monarch butterfly population live in the “corn belt” of the USA = this new gene could have serious repercussions for this organism

31. Canadian Food Inspection Agency Genetically modified foods are currently regulated by the CFIA Genetically modified foods are currently regulated by the CFIA works collaboratively with Environment Canada, Health Canada, and Fisheries and Oceans works collaboratively with Environment Canada, Health Canada, and Fisheries and Oceans Goal: to ensure that products of biotechnology are considered safe to human and animal health and the environment. Goal: to ensure that products of biotechnology are considered safe to human and animal health and the environment. According to the CFIA, the assessment process for GE foods is very rigorous According to the CFIA, the assessment process for GE foods is very rigorous

32. Canadian Food Inspection Agency Assessment process Assessment process Criticisms of process Criticisms of process

33. Conclusion Genetic Modification: Good or Bad?

34. Literature Cited: 1. Canadian Food Inspection Agency. Novel Foods Retrieved April 1, 2002, from the World Wide Web: http://www.inspection.gc.ca/english/plaveg/pbo/pbobbve.shtml http://www.inspection.gc.ca/english/plaveg/pbo/pbobbve.shtml 2. Canadian Food Inspection Agency.(2000) Plant Health and production division, plant biosafety office on Regulatory directive 2000-07: Guidelines for the environmental release of plants with novel traits within confined field trails in Canada. Retrieved April 4, 2002, from the World Wide Web: http://www.inspection.gc.ca/english/plaveg/pbo/dir/dir0007e.shtml 3. Draper, D. (1998). Our Environment: A Canadian Perspective 1st Ed. Scarborough: Thompson Canada Lmt. 4. Draper, D. (2002). Our Environment: A Canadian Perspective 2nd Ed. Scarborough: Thompson Canada Lmt. 5. Jones, L. (1999, February 27). Genetically modified foods. British Medical Journal. [Journal, Online]. Retrieved April 1, 2002, from the World Wide Web: http://www.findarticles.com/cf_0m0999/7183_318/5417903/print.jhtml http://www.findarticles.com/cf_0m0999/7183_318/5417903/print.jhtml 6. Health Canada. Retrieved April 1, 2002, from the World Wide Web: http://www.hc-sc.gc.ca/food-aliment/mh-dm/ofb-bba/nfi- ani/e_novel_foods_and_ingredient.html http://www.hc-sc.gc.ca/food-aliment/mh-dm/ofb-bba/nfi- ani/e_novel_foods_and_ingredient.html 7. Health Canada. A Bureau of Food Policy Integration (Food Directorate) Response to: Food Safety of GM Crops in Canada: toxicity and allergenicity: Retrieved April 5, 2002 from the World Wide Web: http://www.hc-sc.gc.ca/food-aliment/mh-dm/ofb-bba/nfi- ani/e_health_canada_response_gmo.html http://www.hc-sc.gc.ca/food-aliment/mh-dm/ofb-bba/nfi- ani/e_health_canada_response_gmo.html 8. McCalla, D.R. (2000). Why we should proceed cautiously with plant biotechnology? Retrieved April 4, 2002, from the World Wide Web: http://www.canadians.org/ge-alert/ http://www.canadians.org/ge-alert/ 9. Mitchell, B.C. (1997). Resource and Environmental Management 2nd Ed. Harlow: Pearson Education Lmt. 10. Reason Online. Retrieved April 1, 2002, from the World Wide Web: http://reason.com/bi/bi-gmf.shtm http://reason.com/bi/bi-gmf.shtm 12. Steiner, M. (2000, May 9) Petition to the Auditor General: By the Sierra Legal Defense Fund. Retrieved April 6, 2002, from the World Wide Web: http://www.sierralegal.org/m%5Farchive/2000/pr00%5F05%5F09b.htm http://www.sierralegal.org/m%5Farchive/2000/pr00%5F05%5F09b.htm 13. Sizer, F., Whitney, E. (1997). Nutrition Concepts and Controversies 7 th Edition. Waltsworth publishing Company: Belmont Ca. 13. Sizer, F., Whitney, E. (1997). Nutrition Concepts and Controversies 7 th Edition. Waltsworth publishing Company: Belmont Ca. 14. Whitney, E.N., Rolfes, S.R. (2002). Understanding Nutrition. 9 th Ed. Wadsworth Group: Belmont Ca. 14. Whitney, E.N., Rolfes, S.R. (2002). Understanding Nutrition. 9 th Ed. Wadsworth Group: Belmont Ca. 15. http://allergies.about.com/library/blificbio.htm 15. http://allergies.about.com/library/blificbio.htmhttp://allergies.about.com/library/blificbio.htm 16. Human Genome project(2004).: http://www.ornl.gov/sci/techresources/Human_Genome/elsi/gmfood.shtml 16. Human Genome project(2004).: http://www.ornl.gov/sci/techresources/Human_Genome/elsi/gmfood.shtml http://www.ornl.gov/sci/techresources/Human_Genome/elsi/gmfood.shtml 17. Bayer CropScience (2004). http://www.bayercropscience.com/bayer/cropscience/cscms.nsf/id/OurCust omers http://www.bayercropscience.com/bayer/cropscience/cscms.nsf/id/OurCust omers