1. Figure 1 Lymphocytes during the disease
process of rheumatoid arthritis in different tissue environments
Figure 1 | Lymphocytes during the disease process of rheumatoid arthritis in different tissue environments. The disease process of rheumatoid arthritis (RA) involves multiple tissue environments and extends over several decades. An early event is the breakdown of immunologic tolerance, which occurs in lymphoid tissues. After expansion and maturation of autoreactive lymphocytes, autoantigens are encountered in peripheral tissues, eventually leading to the formation of tertiary lymphoid microstructures and chronic destructive inflammation. The inflamed synovial membrane and the disrupted tissue repair response represent the end stage of RA.
Weyand, C. M. & Goronzy, J. J. (2017) Immunometabolism in early and late stages of rheumatoid arthritis
Nat. Rev. Rheumatol. doi: /nrrheum