1. of different experimental arthritis models
Figure 2 Overview of the role of IL‑17/IL‑17RA and IL‑23 signalling during the pathogenesis
of different experimental arthritis models
Figure 2 | Overview of the role of IL-17/IL-17RA and IL-23 signalling during the pathogenesis of different experimental arthritis models. a | The effects of IL-23p19 knock-out, IL-17A knock-out and IL-17RA knock-out on the development of autoimmune CIA. Therapeutic intervention with neutralization of IL-23p19 or IL-17A during different stages of CIA either has no effect or has beneficial effects on the progression of the disease, as assessed by clinical scores. b | The effect of IL-23p19 knock-out and IL-17RA knock-out on the development of a T-cell-driven monoarthritis using the mBSA AIA model. The effect of neutralizing IL-17A or IL-23p19 on the progression of arthritis as well as during a flare-up of the arthritis was monitored by clinical scores. Abbreviations: AIA, antigen-induced arthritis; CII, type II collagen; CIA, collagen-induced arthritis; FcγR, Fcγ receptor; IC, immune complex, IL-17RA, IL-17 receptor subunit A; mBSA, methylated bovine serum albumin; TH cell, T helper cell.
Lubberts, E. (2015) The IL‑23–IL‑17 axis in inflammatory arthritis
Nat. Rev. Rheumatol. doi: /nrrheum