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Figure 2 Proinflammatory mechanisms in CKD

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Presentation on theme: "Figure 2 Proinflammatory mechanisms in CKD"— Presentation transcript:

1 Figure 2 Proinflammatory mechanisms in CKD
Figure 2 | Proinflammatory mechanisms in CKD. High levels of cytokines, metabolic acidosis, volume and sodium expansion, the presence of uraemic toxins and sleep apnoea (owing to sympathetic overactivity) contribute to insulin resistance in chronic kidney disease (CKD). Proinflammatory mechanisms activated by renal dysfunction might accelerate progression of CKD. Insulin resistance triggers inflammation and vice versa. Genetic and epigenetic factors act as modifiers of endogenous and environmental factors responsible for inflammation in CKD. Zoccali, C. et al. (2017) The systemic nature of CKD Nat. Rev. Nephrol. doi: /nrneph

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