Autoimmune polyendocrinopathy Polyglandular autoimmune syndrome.

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Presentation transcript:

Autoimmune polyendocrinopathy Polyglandular autoimmune syndrome

Endocrine glands Pancreas Ovaries Testes Thyroid Parathyroids Adrenals

PAS group of disorders characterized by: endocrine tissue destruction leading to multiple glands malfunction. Genetics play a role in determining who develops PAS.

4 types Type 1 PAS: Common in age of 10 to 12 yrs. Rare genetic starts with chronic candidiasis progresses to parathyroids and adrenals resulting into hypoparathyroidism and Addison's disease. Other related autoimmune disorders can develop over the years.

Type 2 In adults women three times Starts with adrenals (Addison’s disease) and progresses to: -Thyroid (hypothyroidism) -Pancreas (Type 1 diabetes mellitus)

Type 3 Mainly affects women in their 30's. Starts with thyroid dysfunction and progresses to other autoimmune disorders including diabetes, pernicious anemia, coeliac disease and many of the same conditions that occur in PAS 1 and 2. It doesn't typically include adrenal gland malfunction.

Type 4 have two or more autoimmune endocrine diseases that don't follow the typical pattern for the other types of PAS. For instance, a person may have type 1 diabetes first and then goes on to develop coeliac disease without adrenal or thyroid involvement.

Treatment Replacement of the deficient hormone(s)