NovaMin

What is NovaMin®? A “high-tech” active ingredient used in the most innovative professional dental products. Material Description Technical Breakdown NovaMin is a breakthrough remineralization technology. A tasteless white powder form. NovaMin amplifies the natural protective and repair mechanisms for teeth and gums. Extensively proven in clinical and scientific studies at leading dental schools around the world. Comprised of calcium, sodium, phosphorous and silica, all natural elements found in the body Chemical name is Calcium Sodium Phosphosilicate NovaMin is recognized as the only man made ingredient that directly leads to the formation of new tooth mineral (HCA)

What Does NovaMin® Do? Repairs Surface Lesions Forms biomimetic HCA on tooth dentin and enamel surface lesions Reduces Sensitivity Occludes dentin tubules: forms a protective biomimetic HCA layer. Improves Gingival Health Antimicrobial properties & Anti-inflammatory properties reduce gingivitis.

The NovaMin® Solution Hard Tissue Benefits

The NovaMin® Solution Soft Tissue Benefits

NovaMin: How it Starts NovaMin is also called “calcium sodium phosphosilicate”. It is made from elements naturally found in healthy teeth and bones: Calcium ( ), Phosphorus ( ), Sodium ( ) and Silicon ( )

Step 1: pH Elevation NovaMin reacts with saliva. Na+ ions release, elevating pH into the range essential for HCA formation. +H2O pH 8.0-8.5

Step 2: Mineral Release Ca2+ and P5+ ions are released, saturating saliva with the ions needed for remineralization. Ca2+ P5+

Step 3: Bacterial Kill Na+ and Ca2+ ions overwhelm bacterial cells’ ability to regulate their water content, leading to lysis (cell death) of harmful bacteria in the mouth. F. Nucleatum S. Mutans A.Naeslundii -99.999% -99.99% S. Sanguis -99.99999% -99.999%

Demineralized lesions attract Step 4: Crystal Building Demineralized lesions attract Ca2+ and P5+ ions, where they build new HCA crystal to remineralize the defect from the bottom up. Enamel Crystal Prism Tooth Mineral Structure - Hydroxy-carbonate Apatite (“HCA”)

Step 5: Time Release NovaMin particles adhere to tooth surfaces for up to 7 days, continuing to release Na+, Ca2+, and P5+ ions to maintain elevated pH at the tooth surface and foster remineralization over time. Enamel Crystal Prism Tooth Mineral Structure - Hydroxy-carbonate Apatite (“HCA”)

Remineralization of Dentin & Enamel In-vitro Study – In-Situ Models Surface Lesion In-vitro Surface Abrasion In-Situ Exposed Dentin In-vitro Before Treatment After Treatment

NovaMin Product Focuses Sensitivity: Faster & better results Addresses symptom, not cause. Gingivitis: Faster results Less controversial ingredient Root Caries/Remineralization: Adult caries predominantly related to hyposalivation. NovaMin directly addresses this etiology.

NovaMin & Sensitivity NovaMin Therapy Paste Results Clinical Results Vs. Placebo

NovaMin & Sensitivity NovaMin Therapy Paste Results Clinical Results Vs. Other Actives

NovaMin vs. Fluoride Remineralization of Dentin NTI-UCSF In-vitro Study – Dentin Remin/Demin Model Product Tested Code 7.5% NM/1100 ppm MFP 1 7.5% NM 2 Company CR 5000 ppm NaF 3 Company CG 1.1 ppm MFP 4 0% NM/O ppm F 5

NovaMin and Gingivitis Anti-Microbial Properties

NovaMin and Gingivitis Pilot Clinical Study – Gingival Bleeding Index -59%

NovaMin and Gingivitis Pilot Clinical Study – Plaque Index

NovaMin/Fluoride Enamel Remineralization In-vitro Study – Remin/Demin Model Surface Lesion ~ 100µm Sound Enamel Sound Enamel Sound Enamel Demineralized Untreated Sample Fluoride Dentifrice Treated Sample NovaMin Dentifrice + F Treated Sample

NovaMin/Fluoride Enamel Remineralization In-vitro Study – Remin/Demin Model -30% -45% p<0.001