CACHE Systems Biology Task Force Fall Trustee Meeting Nashville, TN November 2009

Systems Biology Task Force Develop educational materials for the undergraduate ChE curriculum Develop educational materials for the undergraduate ChE curriculum Provide training opportunities for graduate students interested in systems biology research Provide training opportunities for graduate students interested in systems biology research Increase the visibility of systems biology in ChE education Increase the visibility of systems biology in ChE education Offer the Foundations of Systems Biology in Engineering (FOSBE) conference series Offer the Foundations of Systems Biology in Engineering (FOSBE) conference series

Task Force Members Mike Henson (UMass, Chair) Mike Henson (UMass, Chair) Frank Doyle (UCSB) Frank Doyle (UCSB) Vassily Hatzimanikas (EPFL) Vassily Hatzimanikas (EPFL) Marianthi Ierapetritou (Rutgers) Marianthi Ierapetritou (Rutgers) Claire Komives (San Jose State) Claire Komives (San Jose State) Costas Maranas (Penn State) Costas Maranas (Penn State) Tunde Ogunnaike (Delaware) Tunde Ogunnaike (Delaware) Bob Parker (Pittsburgh) Bob Parker (Pittsburgh) Linda Petzold (UCSB) Linda Petzold (UCSB) Chen Su (Eli Lilly) Chen Su (Eli Lilly) Dane Wittrup (MIT) Dane Wittrup (MIT) Bold indicates CACHE trustee

FOSBE rd Conference on Foundations of Systems Biology in Engineering Denver, Colorado Inverness Hotel & Conference Center August 9-12, Sponsored by CACHE and the Systems Biology Task Force

Technical Program & Sponsors SundayMondayTuesdayWednesday Morning Training Workshop Drug Development Network Modeling Circadian Systems Afternoon Training Workshop Free time Federal Funding Panel Free time EveningReception Alternative Fuels Education Synthetic Biology NightKeynote Poster Session I Poster Session II Award Ceremony & Banquet

Student Training Workshop Objectives Objectives Tutorial introductions to several important areas of systems biology Tutorial introductions to several important areas of systems biology Targeted at graduate students, post-doctoral researchers & young faculty entering the field Targeted at graduate students, post-doctoral researchers & young faculty entering the field Further CACHE goal of providing educational training Further CACHE goal of providing educational training Structure Structure 7 leading systems biology researchers & practitioners 7 leading systems biology researchers & practitioners 5 academic speakers covering theoretical topics & important applications 5 academic speakers covering theoretical topics & important applications 2 industrial speakers covering systems biology impact in the pharmaceutical industry 2 industrial speakers covering systems biology impact in the pharmaceutical industry

Workshop Speakers Mathematical Modeling Methodology at Amgen (David Balaban, Amgen) Mathematical Modeling Methodology at Amgen (David Balaban, Amgen) Network Robustness (Frank Doyle, UCSB ) Network Robustness (Frank Doyle, UCSB ) An Example of How Systems Biology is Contributing to Drug Discovery in the Pharmaceutical Setting (Bruce Gomes, Pfizer) An Example of How Systems Biology is Contributing to Drug Discovery in the Pharmaceutical Setting (Bruce Gomes, Pfizer) Bioenergetics and Biochemical Network Thermodynamics (Vassily Hatzimanikatis, EPFL) Bioenergetics and Biochemical Network Thermodynamics (Vassily Hatzimanikatis, EPFL) Circadian Entrainment and Rhythm Generation (Erik Herzog, Washington U and Hiroki Ueda, Kyushu U) Circadian Entrainment and Rhythm Generation (Erik Herzog, Washington U and Hiroki Ueda, Kyushu U) Stochastic Chemical Kinetics (Dam Gillespie, Gillespie Consulting) Stochastic Chemical Kinetics (Dam Gillespie, Gillespie Consulting) Parameter Estimation and Structure Identification in Metabolic Networks (Eberhard Voit, Georgia Tech) Parameter Estimation and Structure Identification in Metabolic Networks (Eberhard Voit, Georgia Tech)

Workshop Outcomes Attendance Attendance 42 total attendees 42 total attendees 19 graduate & post-doctoral students 19 graduate & post-doctoral students 11 professors, mostly assistant professors 11 professors, mostly assistant professors 1 industry attendee 1 industry attendee 3 federal government attendees 3 federal government attendees Feedback Feedback Overall response very positive Overall response very positive Several attendees felt the workshop was the most valuable portion of the conference Several attendees felt the workshop was the most valuable portion of the conference Future plans Future plans Gathering presentations for website posting Gathering presentations for website posting Second workshop planned at FOSBE 2011 Second workshop planned at FOSBE 2011

Task Force Update Tunde Ogunnaike Tunde Ogunnaike Accepted position as task force chair Accepted position as task force chair Decided not to run for trustee re-election Decided not to run for trustee re-election Mike Henson will assume chair position Mike Henson will assume chair position Have mainly focused on FOSBE 2009 & 2011 Have mainly focused on FOSBE 2009 & 2011 Possible initiatives Possible initiatives Change task force members and expand focus Change task force members and expand focus Distribution of materials from Bioengineering Educational Materials Bank ( Distribution of materials from Bioengineering Educational Materials Bank ( Preparation of NIH proposal for educational modules Preparation of NIH proposal for educational modules