Vesicular Transport III. N-linked glycosylation because sugar is added to N of asparagine. original precursor oligosaccharide added to most proteins in.

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Presentation transcript:

Vesicular Transport III

N-linked glycosylation because sugar is added to N of asparagine. original precursor oligosaccharide added to most proteins in the ER

Oligosaccharide chains are processed in the Golgi common core complex high-mannose

Vesicular transport model

Cisternal Maturation Model

Lysosome interior is different from cytosol

Detection of acid phosphatase in lysosomes Small spheres may be vesicles delivering the enzyme from the Golgi Apparatus

Structure of oligosaccharide that directs lysosome enzyme to the lysosome

3 pathways to degradation in the lysosome

Autophagosome with mitochondrion and peroxisome

3 possible fates of receptor proteins in an epithelial cell

Phagocyte ingesting chemically altered red blood cells

A neutrophil phagocytosing a bacterium

Formation of clathrin coated membrane from the plasma membrane

Caveolae in the plasma membrane of a fibroblast

Low Density Lipoprotein particle transports cholesterol in the blood 1500 cholesterol molecules esterified to long chain fatty acids in one particle

Normal LDL receptors facilitate transport of cholesteryl esters in clathrin coated vesicles

Defective LDL receptor protein causes high levels of blood cholesterol and heart disease

cholesterol is released in lysosome

opiod receptor green transferin red