Ribozymes (RNA Enzymes) David Peterson. Enzymes Catalyze reactions Very specific Act on substrates Active site.

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Presentation transcript:

Ribozymes (RNA Enzymes) David Peterson

Enzymes Catalyze reactions Very specific Act on substrates Active site

Enzymes Bind Substrates

Structure of RNA and DNA

DNA RNA Protein Information Flow in Cells The Central Dogma of Molecular Biology TranscriptionTranslation

Semiconservative DNA Replication

Amino acids combine to make peptides and proteins

mRNA Splicing

Ribosomes Site of protein synthesis Made of RNA and protein

Tetrahymena thermophila

Self-Splicing RNA Cech, Zaug, and Grabowski Cell 27:

Single-Stranded RNA Can Form Intramolecular Base Pairs

Intramolecular H-bonds in the Tetrahymena Ribozyme

3D Structure of the Self-Splicing Intron

Ribosomes Site of protein synthesis Made of RNA and protein

Tom Cech Sidney Altman Nobel Prize in Chemistry 1989

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