Alchemist TM II: Capacity, reproducibility and efficiency of an high-throughput crystallization screen preparation system. Craig Sterling Director of Business Development Rigaku

CrystalTrak TM Information Flow & Management Automated Protein Crystallization Platform Alchemist TM II Screen Maker Minstrel HT & Gallery 700 Incubators Imaging and Incubation Phoenix RE Experimental Plate Setup Integration Module Including Robotic Arm, plate and block storage, mixing station, piercing station, and foil and tape sealing

CrystalMation TM Features  Alchemist TM II, Phoenix RE, Minstrel TM HT imaging system and Gallery TM 700 incubators operate independently or as part of the completely integrated CrystalMation system  Allows instruments to be added over time to meet budgets  Easy and seamless integration  CrystalTrak TM relational database application  Easy-to-use design is manageable by tech level personnel  Mixing, Piercing & Sealing accessories for CrystalMation TM system  Low cost operation of $10 per plate including maintenance costs and chemical costs

CrystalTrak TM  CrystalTrak seamlessly integrates the Rigaku Crystallization instruments, offering labs a complete end-to-end solution  Relational database tracks all of the necessary information used in crystallization trials such as chemicals, screens, protein samples, plate type information, images, and annotations  CrystalTrak simplifies and aids in the crystallization process by providing tools that enable users to greatly improve crystallization trial productivity with less user intervention.  One-click optimization tools  Intuitive screen design tools  CrystalTrak Web offers remote access to data

Custom Screen Maker – The Alchemist II  The best accuracy in the industry for handling stock solutions of all viscosities, dispensing volumes as low as 1µl using the Tapper TM technology  Produce liquid formulations without wasting chemicals during every cleaning, priming and wash cycle  74 Barcoded easy to swap reagents  No tedious setup, cleaning and maintenance  Dedicated syringe for each reagent  Easy screen design with CrystalTrak

NEW Seal-tight BirdFeeders TM  New threaded cap, Seal-tight design  Long-term storage of stock solutions on deck  Works with standard stock solution bottles  Barcode Tracking of birdfeeders and stock solutions  Autoclave-able design  Easy-pour design for replacement of stocks  Four different stock solution sizes  20ml in Birdfeeder with cap  Good for expensive stocks and additives  125ml Nalgene bottles  250ml Nalgene bottles  Three Syringe sizes (Eppendorf)  100ul  1ml  10ml

Alchemist II

CrystalTrak TM Information Flow & Management Automated Protein Crystallization Platform Alchemist TM II Screen Maker Minstrel HT & Gallery 700 Incubators Imaging and Incubation Phoenix RE Experimental Plate Setup Integration Module Including Robotic Arm, plate and block storage, mixing station, piercing station, and foil and tape sealing