Notes 7.14.1: Blood Magette Eudora High School

Volume and Composition Varies due to: Size Hydration Body composition 8% of body weight About 5 Liters Magette Eudora High School

Figure 14.3 Page 531 Magette Eudora High School

“Hemocytoblast”: -Type of stem cell -Red bone marrow Magette Eudora High School

Red Blood Cells -”Erythrocytes” -95% of cellular blood Magette Eudora High School

-<5% of cellular blood Platelets -”Thrombocytes” -<5% of cellular blood Magette Eudora High School

-<1% of cellular blood White Blood Cells -”Leukocytes” -<1% of cellular blood Magette Eudora High School

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Erythrocytes “Red Cells” 95% of cellular blood Bi-Concave disc Non-nucleated Hemoglobin 1/3 of volume 4-7 million/mm3 Magette Eudora High School

Erythrocytes Magette Eudora High School

How Much Did You Give? Magette Eudora High School

How Much Did You Give? 4-7 million RBC’s /mm3 of blood Magette Eudora High School

How Much Did You Give? 4-7 million RBC’s /mm3 of blood 1 mm3 = 100 mL Magette Eudora High School

How Much Did You Give? 4-7 million RBC’s /mm3 of blood 1 mm3 = 100 mL You gave 1 pint Magette Eudora High School

How Much Did You Give? 4-7 million RBC’s /mm3 of blood 1 mm3 = 100 mL You gave 1 pint 1 pint = 473.2 mL Magette Eudora High School

How Much Did You Give? 4-7 million RBC’s /mm3 of blood 1 mm3 = 100 mL You gave 1 pint 1 pint = 473.2 mL 4,000,000 x 100 x 473.2 = 189,280,000,000 7,000,000 x 100 x 473.2 = 331,240,000,000 Magette Eudora High School

How Much Did You Give? 4-7 million RBC’s /mm3 of blood 1 mm3 = 100 mL You gave 1 pint 1 pint = 473.2 mL 4,000,000 x 100 x 473.2 = 189,280,000,000 7,000,000 x 100 x 473.2 = 331,240,000,000 You gave 190-330 Billion erythrocytes! Magette Eudora High School

Hemoglobin 1/3 of RBC volume Globular protein Magette Eudora High School

Hemoglobin 1/3 of RBC volume Globular protein “Heme” groups containing iron Magette Eudora High School

Hemoglobin 1/3 of RBC volume Globular protein “Heme” groups containing iron Magette Eudora High School

Hemoglobin 1/3 of RBC volume Globular protein “Heme” groups containing iron Magette Eudora High School

Hemoglobin 1/3 of RBC volume Globular protein “Heme” groups containing iron Carries oxygen Similar to myoglobin Responsible for red color of blood Magette Eudora High School

Questions: Is blood sometimes blue? Magette Eudora High School

Questions: Is blood sometimes blue? How does this relate to what we know about iron-deficiency anemia? Magette Eudora High School

Questions: Is blood sometimes blue? How does this relate to what we know about iron-deficiency anemia? How do the CSI people get DNA from blood? Magette Eudora High School

RBC Production Red Bone Marrow “Erythropoiesis” Red Bone Marrow Erythropoietin: hormone released from kidneys and liver that stimulates production of RBC’s Magette Eudora High School

Control of RBC Production Negative Feedback: Magette Eudora High School

Control of RBC Production Negative Feedback: 1.Trigger Magette Eudora High School

Control of RBC Production Negative Feedback: 1.Trigger 2.Hormone Release Magette Eudora High School

Control of RBC Production Negative Feedback: 1.Trigger 2.Hormone Release 3.Result Magette Eudora High School

Control of RBC Production Negative Feedback: 1.Trigger 2.Hormone Release 3.Result 4.Inhibition Magette Eudora High School

Control of RBC Production Negative Feedback: 1.Trigger 2.Hormone Release 3.Result 4.Inhibition Magette Eudora High School

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RBC Breakdown Liver and spleen RBC is destroyed by macrophages Hemoglobin is broken down into “heme” groups and globular proteins Proteins are broken down to amino acids and metabolized Magette Eudora High School

RBC Breakdown Heme group is broken down into iron and biliverdin Iron is stored and/or reused Biliverdin is converted to orange pigment (bilirubin) “Bilis-” are secreted in bile Magette Eudora High School

Leukocytes Magette Eudora High School

Thrombocytes Magette Eudora High School

Plasma Magette Eudora High School

Plasma Magette Eudora High School

Plasma Magette Eudora High School

Plasma Magette Eudora High School