Also known as lymphoplasmacytic lymphoma A rare type of non-Hodgkin lymphoma WM affects lymphoplasmacytic (LPL) Cells B-Cells LPL Cells Plasma Cells Abs.

Slides:

Advertisements

Similar presentations

B-2.7 Summarize how cell regulation controls and coordinates cell growth and division and allows cells to respond to the environment, and recognize.

Advertisements

Chapter 9 Slides PART 2 Cellular Reproduction. 2 Interphase Prophase Metaphase Anaphase Telophase Name the Mitotic Stages:

Cancer Cancer originates in dividing cells –Intestinal lining (colon) –Lung tissue –Breast tissue (glands/ducts) –Prostate (gland) –White blood cells.

CLS 404 Immunology Protein Abnormalities

What is it? Treatment options Prevention.  Disease  Cells grow and divide uncontrollably  No way to stop  Damage to body around them.

Cancer Cells Gone Wild!. Cancer Cell Surrounded by T-cells and dead.

Focusing on Hodgkin Disease

CELL DIVISION AND CANCER Unit 7 - Mitosis. Mitosis  All cells in your body divide  In children and teens, cells divide to assist in growth  In adults,

LEUKEMIA. What Is It? Leukemia is a type of cancer that starts in the tissue that forms blood.

Chronic lymphocytic leukemia (1)

Chronic Lymphocytic Leukemia (CLL) DEFINITION CLL is a neoplastic disease characterized by proliferation and accumulation (blood, marrow and lymphoid.

Agne Paner, MD Assistant professor of Medicine RUSH University Medical Center.

BY BRANDON HAMM Leukemia. Fever & Night sweat Headaches. Bruising or bleeding easily. Bone or joint pain. A swollen or painful belly from an enlarged.

By:Ashley Druck.  Is cancer that starts in the blood, forming tissues such as the bone marrow and causes large numbers of blood cells to be produced.

Cancer “Mitosis Gone Wild”.

A cancerous cell is caused by a faulty reproduction system. The cell continues to reproduce at a very fast rate When cells reproduce at an abnormally.

Sexual v. Asexual Reproduction. Binary Fission Chromosome Structure Eukaryotic chromosomes contain DNA and protein tightly packed together to from chromatin.

SC430 Molecular Cell Biology

Chronic Non-Infectious: Cancer

Innovative therapeutic modalities in hematologic Malignancies Prof. Nossrat Firusian, Recklinghausen, Germany.

Cancer By: Erionne. What is Cancer Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms new cells as you.

Multiple Myeloma Presented by: Mike Lynch Mike Lynch.

Treatment of Non- Hodgkin’s Lymphoma. Precursor B cell Lymphoblastic Leukemia Remission induction with combination therapy Consolidation phase: –High.

Treatment of B Cell Malignancies: Current and Emerging Strategies Thomas A. Rado, MD, PhD.

10.3 Regulation.

Regulating the Cell Cycle

Cell Cycle and Mitosis Uncontrolled Cell Growth.  Benign Does not spread Does not spread Easily removed Easily removed  Malignant cancer Spreads to.

Fig. 7.6 THE CELL CYCLE. CANCER Fig. 7.9 Cell Cycle Control  Cells that are not directed by the cell cycle control system tend to divide out of control.

KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

Do Now What is cancer? What are some different types of cancer? What causes cancer?

Cancer: Uncontrolled Cell Growth

Notes - Cancer and Cell Division

Chronic lymphocytic leukemia What is C.L.L. ? a chronic disease one particular type of lymphocyte (B-cells) accumulates. not rapidly growing and proliferating.

What is cancer? Mitosis- normal cell division Cancer- uncontrolled cell division (carcinoma) –Develops into a tumor Benign- does not spread –(Not Cancerous)

 What is cancer? How do cancer cells differ from other cells?  Do you know of any types of cancer? If so…name them.

Taylor Edwards. What is Leukemia? Leukemia is a type of blood cancer that begins in the bone marrow. The bone marrow starts making abnormal white blood.

LYMPHOMA Malignant transformation of cell in Lymphatic system There are about 600 Lymph Nodes in the body Spleen and gut also have lymphatic tissue.

Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

Lymph is the clear interstitial fluid found between the cells of the body. It enters the lymph vessels by filtration travels to one of the lymph nodes.

Educational Presentation

5.3 Regulation of the Cell Cycle KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

Cancer Objective What is Cancer? Cancer is uncontrolled cell growth. (Mitosis) When you are young, your cells grow fast so because you are growing.

By: Kaylee Copas. What is cancer? Cancer is the uncontrolled growth of abnormal cells in the body. Cancerous cells are also called malignant cells.

White blood cells and their disorders Dr K Hampton Haematologist Royal Hallamshire Hospital.

5.3 Regulation of the Cell Cycle Cell cycle regulation is necessary for healthy growth.

MITOSIS: CELL CYCLE CONTROL. OVERVIEW: Has 4 phases – G 1, S, G 2, and M Driven by specific molecular signals present in the cytoplasm Controlled by a.

Regulation of the Cell Cycle. How does a cell know when to divide and when not to divide?

5.3 Regulation of the Cell Cycle KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

Leukemia By: Manuel Gomez. What is leukemia  Leukemia also called blood cancer  A disease in which the bone marrow and organs that form blood, produce.

Low Grade Lymphomas: Treatment approaches Parameswaran Venugopal, MD Professor of Medicine Rush University Medical Center.

What is cancer? What are some different types of cancer? What causes cancer? Do you know anyone who has suffered from cancer? Do Now.

Treatment for Cancer. Surgery Treatment and prognosis depend on severity and spread of the cancer Treatment and prognosis depend on severity and spread.

LESSON 14.3 “Cancer”. Cancer: a group of diseases in which cells divide in an uncontrolled manner. Not contagious Not caused by injury Causes are not.

Leukemia An estimate reveals over 327,520 people in the U.S. are living with Leukemia. In India leukemia is ranked among the list of top cancers affecting.

Cell Cycle Regulation.

KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

Leukemia An estimate reveals over 327,520 people in the U.S. are living with Leukemia. In India leukemia is ranked among the list of top cancers affecting.

10.3 Regulation I. Controls A. Cell growth & division depend on protein signals & other environmental signals II. Checkpoints B. Feedback.

Cell Biology and Cancer

Cancer Treatment.

How I treat Waldenström macroglobulinemia

Objectives: 1. Cancer and the cell cycle checkpoints, reqmts to advance oncogenes tumor suppressor genes 2. 6 Traits of cancerous cells 3. Facts on.

Presentation transcript:

Also known as lymphoplasmacytic lymphoma A rare type of non-Hodgkin lymphoma WM affects lymphoplasmacytic (LPL) Cells B-Cells LPL Cells Plasma Cells Abs In WM – Abnormal LPL cells build up In bone marrow -crowding out healthy blood cells In lymph nodes, spleen, and other organs Abnormal LPL cells IgM Ab Second level

“Macroglobulinemia” means IgM in blood, increasing the thickness of the blood -hyperviscosity WM spreads to blood and bone marrow May spread to lymph nodes, liver, spleen, stomach, intestines, and lungs Develops slowly- may not need treatment for months or years

Watchful waiting Plasmapheresis- Plasma Exchange Reduces thickness of blood A blood cell separator is used Blood is removed through vein Red and white blood cells are separated from plasma Blood cells are mixed with a plasma substitute Blood is returned to body Second level

Chemotherapy Systemic therapy IV, tablet or under the skin Prevents cancer cells from growing and dividing Commonly used chlorambucil (Leukeran ®) fludarabine (Fludara ®) cladribine (Leustat ®) cyclophosphamide bendamustine (Levact ®) Combination Chemotherapy Second level

Corticosteroids Stem Cell or Bone Marrow Transplantation Hematopoietic stem cells- from patient’s own blood or bone marrow Serious risks and sporadic effectiveness Cancerous bone marrow hematopoietic stem cells

Rituximab (Rituxan, Mabthera) Monoclonal antibody that binds to an antigen (CD20) specific to the malignant cell Kills cancer cells or makes susceptible to chemotherapy Ibrutinib (Imbruvica)-FDA approved An inhibitor of BTK (kinase) Shuts down signaling cascade, inhibiting transcription and growth in malignant B-cells

Bortezomib (Velcade ®) Proteasome inhibitor Proteasomes break down proteins in normal and cancerous cells, and Velcade prevents this normal process Alemtuzumab (Campath) Monoclonal antibody that targets CD52- an antigen on tumor cell surface- destroying tumor cells Bendamustine (Treanda) Chemotherapy Used when first diagnosed or upon recurrence

Idelalisib Kinase inhibitor Inhibits P13 kinase, inhibiting tumor cell growth Everolimus (Afinitor) and Temsirolimus (Torisel) mTOR inhibitors Inhibit cell cycle and proliferation of tumor cells Panobinostat Non-selective HDAC inhibitor Inhibits histone deacetylase enzymes, causing apoptosis

Combinations of several chemotherapy drugs, targeted therapies and/or corticosteroids Currently used Monoclonal antibodies (Rituximab) plus chemotherapy Chemotherapy drugs fludarabine and cyclophosphamide Being Studied Bortezomib (proteasome inhibitor), dexamethasone (corticosteroid), and rituximab (monoclonal antibody)