Chapter 1: Intro to Biochemistry C483 Spring 2013

Questions 1.T/F The Golgi apparatus consists of flattened, fluid-filled, membranous sacs and is responsible for chemical modification and sorting of some biomolecules. 2.T/F The endoplasmic reticulum is the major site of RNA synthesis and the site of assembly of ribosomes. 3. Which functional group is shown? A) Primary amine. B) Acyl. C) Amide. D) Anhydride. E) Nitrile.

4. Which is NOT a proper way to form a hydrogen bond? (The symbol "R" represents a general organic group. The hydrogen bonding is represented by dashed lines.) 5. The aggregation of nonpolar molecules or groups in water is thermodynamically due to the A) increased entropy of the nonpolar molecules when they associate. B) decreased enthalpy of the system. C) increased entropy of the water molecules. D) very strong van der Waals forces among the nonpolar molecules or groups. 6. Cells keep the osmotic pressure from being too great by A) existing in hypertonic solutions. B) making macromolecules from smaller molecules. C) existing in a hypotonic solution. D) existing in an isotonic solution. E) Both B and D.

Biological Chemistry Cartoon picture of a virus Nucleic acid wrapped in protein shell Structural biology Biochemistry Chemical biology We will study a coronavirus in discussion section

On the atomic level

Major Topics

Organic Chemistry Review: Section 1.2

Biology Review: Sections Know functions of organellesBe able to describe cytosol

Chapter 2: WATER Properties of water based on H-bonding – Density – Specific heat – Heat of vaporization

Water Solubility Solvation of particles based on intermolecular interactions – Polar molecules – Ionic substances

Solution Chemistry Diffusion Osmotic Pressure How does formation of glycogen affect osmotic pressure?

Water and Nonpolar Compounds Nonpolar compounds do not dissolve in water—they aggregate to minimize surface area Hydrophobic effect Driven by minimization of ordering of water (increases the entropy of solution)

In Discussion Section Section 2.5 Electrostatic interactions – Charge-charge – Hydrogen bonding – Van der Waals Section 1.4, 2.6 Energetics of reactions of water – Condensation vs. hydrolysis – Thermodynamic stability – Kinetci stability

Answers to Questions 1.T 2.F 3.C 4.II 5.C 6.E